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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alsoKnownAs
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gptkb:Heat_shock_protein_HSP_90-alpha
gptkb:HSP90AA1
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gptkbp:encodedBy
|
HSP90AA1 gene
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gptkbp:expressedIn
|
most tissues
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gptkbp:family
|
gptkb:HSP90_family
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gptkbp:foundIn
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gptkb:Homo_sapiens
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gptkbp:function
|
protein folding
cellular stress response
molecular chaperone
stabilization of proteins
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|
https://www.w3.org/2000/01/rdf-schema#label
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HSP 90-alpha
|
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gptkbp:interactsWith
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gptkb:steroid_hormone_receptors
gptkb:kinases
transcription factors
|
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gptkbp:involvedIn
|
signal transduction
protein degradation
cell cycle control
response to heat shock
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gptkbp:length
|
732 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 14q32.31
|
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gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
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|
gptkbp:molecularWeight
|
~90 kDa
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Saccharomyces_cerevisiae
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
2CG9
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
induced by heat shock
regulated by HSF1
|
|
gptkbp:significance
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:structure
|
homodimer
C-terminal domain
ATPase domain
|
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gptkbp:subunit
|
HSP90 chaperone complex
|
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gptkbp:target
|
gptkb:HSP90_inhibitors
|
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gptkbp:UniProtID
|
gptkb:P07900
|
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gptkbp:bfsParent
|
gptkb:HSP90AA1
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gptkbp:bfsLayer
|
8
|