Heat shock protein HSP 90-alpha

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:HSP90AA1
gptkbp:coChaperone	gptkb:HOP gptkb:PP5 gptkb:CHIP gptkb:Cdc37 gptkb:FKBP51 gptkb:FKBP52 gptkb:AHA1 gptkb:CDC37 p23 SGT1
gptkbp:encodedBy	HSP90AA1 gene
gptkbp:expressedIn	most tissues
gptkbp:family	gptkb:heat_shock_protein_90_family
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	gptkb:cellular_stress_response gptkb:molecular_chaperone protein folding stabilization of proteins
gptkbp:hasIsoform	gptkb:HSP90
gptkbp:inhibitedBy	gptkb:geldanamycin gptkb:radicicol
gptkbp:interactsWith	gptkb:steroid_hormone_receptors gptkb:kinases transcription factors
gptkbp:length	732 amino acids
gptkbp:locatedOnChromosome	chromosome 14q32.31
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:mainTerminal	gptkb:GO:0006457_(protein_folding) GO:0005524 (ATP binding) GO:0006950 (response to stress)
gptkbp:molecularWeight	~90 kDa
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Saccharomyces_cerevisiae gptkb:Drosophila_melanogaster
gptkbp:PDB	2CG9
gptkbp:postTranslationalModification	phosphorylation ubiquitination acetylation
gptkbp:regulates	induced by heat shock regulated by HSF1
gptkbp:requires	cell viability
gptkbp:significance	target for cancer therapy
gptkbp:structure	homodimer
gptkbp:UniProtID	gptkb:P07900
gptkbp:bfsParent	gptkb:HSP90AA1
gptkbp:bfsLayer	8
http://www.w3.org/2000/01/rdf-schema#label	Heat shock protein HSP 90-alpha