|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:ApoA-I
gptkb:ApoA1
Apolipoprotein AI
|
|
gptkbp:associatedWith
|
gptkb:Tangier_disease
gptkb:familial_HDL_deficiency
|
|
gptkbp:database
|
HGNC:600
Ensembl:ENSG00000118137
GeneID:335
OMIM:107680
PDB:2A01
Reactome:R-HSA-194068
UniProt:P07900
|
|
gptkbp:disulfideBond
|
none
|
|
gptkbp:enzymeRegulation
|
activates LCAT
|
|
gptkbp:function
|
major protein component of high-density lipoprotein (HDL) in plasma
|
|
gptkbp:gene
|
gptkb:APOA1
|
|
gptkbp:hasBiomarker
|
cardiovascular disease risk
|
|
gptkbp:hasIsoform
|
ApoA-I mature protein
ApoA-I preproprotein
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P07900
|
|
gptkbp:interactsWith
|
gptkb:LCAT
gptkb:ABCA1
gptkb:SR-BI
CETP
|
|
gptkbp:involvedIn
|
reverse cholesterol transport
cholesterol transport
|
|
gptkbp:locatedOnChromosome
|
11
|
|
gptkbp:location
|
11q23-q24
|
|
gptkbp:massSpectrometry
|
detected in plasma
|
|
gptkbp:molecularWeight
|
30759 Da
|
|
gptkbp:name
|
gptkb:Apolipoprotein_A-I
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
lipid metabolism
cholesterol efflux
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycation
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:sequence
|
267
|
|
gptkbp:sequenceStatus
|
complete
|
|
gptkbp:signalPeptide
|
present
|
|
gptkbp:structure
|
amphipathic alpha-helix
|
|
gptkbp:subcellularLocation
|
extracellular region
secreted
|
|
gptkbp:tissue_specificity
|
gptkb:small_intestine
liver
|
|
gptkbp:UniProtID
|
gptkb:P07900
|
|
gptkbp:bfsParent
|
gptkb:14q32.33_(HSP90AA1)
gptkb:HSP90AA1
gptkb:Heat_Shock_Protein_90
|
|
gptkbp:bfsLayer
|
8
|