|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:Heat_shock_protein_HSP_90-alpha
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
signal transduction
protein degradation
apoptosis regulation
cell cycle control
|
|
gptkbp:coChaperone
|
gptkb:Cdc37
gptkb:Hop
p23
|
|
gptkbp:encodedBy
|
HSP90AA1 gene
|
|
gptkbp:expressedIn
|
most tissues
|
|
gptkbp:function
|
molecular chaperone
|
|
gptkbp:GOID
|
GO:0005524
GO:0006457
GO:0006950
|
|
gptkbp:hasIsoform
|
gptkb:HSP90_family
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HSP90A
|
|
gptkbp:interactsWith
|
gptkb:HSP70
gptkb:AHA1
gptkb:CDC37
|
|
gptkbp:involvedIn
|
protein folding
cellular stress response
|
|
gptkbp:locatedOnChromosome
|
chromosome 14q32.31
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~90 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Saccharomyces_cerevisiae
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
2CG9
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
induced by heat shock
|
|
gptkbp:requires
|
cell survival
|
|
gptkbp:sequence
|
732 amino acids
|
|
gptkbp:significance
|
therapeutic target
biomarker for cancer
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:target
|
gptkb:HSP90_inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P07900
|
|
gptkbp:bfsParent
|
gptkb:14q32.33_(HSP90AA1)
gptkb:HSP90AA1
|
|
gptkbp:bfsLayer
|
8
|