Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:HSP90A
gptkb:Heat_shock_protein_HSP_90-alpha HSP90 alpha |
| gptkbp:component |
gptkb:nucleus
cytosol extracellular exosome |
| gptkbp:encodedBy |
HSP90AA1 gene
|
| gptkbp:function |
protein folding
ATP binding protein binding molecular chaperone chaperone binding stabilization of proteins against heat stress assists in protein degradation |
| gptkbp:GOProcess |
regulation of apoptosis
protein folding response to heat |
| https://www.w3.org/2000/01/rdf-schema#label |
HSP90AA1 protein
|
| gptkbp:interactsWith |
gptkb:Cdc37
gptkb:FKBP51 gptkb:FKBP52 gptkb:HSP70 gptkb:AHA1 gptkb:CDC37 p23 |
| gptkbp:involvedIn |
signal transduction
cell cycle control cellular response to stress protein homeostasis |
| gptkbp:locatedOnChromosome |
14q32.31
|
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:molecularWeight |
~90 kDa
|
| gptkbp:orthologIn |
Hsp83 (Drosophila melanogaster)
Hsp90ab1 (Mus musculus) |
| gptkbp:postTranslationalModification |
phosphorylation
ubiquitination acetylation |
| gptkbp:significance |
target for cancer therapy
implicated in cancer associated with neurodegenerative diseases |
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:structure |
homodimer
contains C-terminal domain contains N-terminal domain contains ATPase domain |
| gptkbp:UniProtID |
gptkb:P07900
|
| gptkbp:bfsParent |
gptkb:HSP90AA1
|
| gptkbp:bfsLayer |
8
|