|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:Heat_shock_protein_70
|
|
gptkbp:assistsIn
|
antigen presentation
degradation of misfolded proteins
refolding denatured proteins
|
|
gptkbp:conservedIn
|
all domains of life
|
|
gptkbp:contains
|
ATPase domain
substrate-binding domain
|
|
gptkbp:example
|
gptkb:HSPA1A
gptkb:HSPA1B
gptkb:HSPA8
|
|
gptkbp:firstDescribed
|
1970s
|
|
gptkbp:foundIn
|
gptkb:Bacteria
archaea
eukaryotes
|
|
gptkbp:function
|
gptkb:molecular_chaperone
protein folding
assists in protein transport across membranes
prevention of protein aggregation
|
|
gptkbp:inducedBy
|
heat shock
cellular stress
|
|
gptkbp:inhibitedBy
|
gptkb:PES
gptkb:VER-155008
|
|
gptkbp:interactsWith
|
gptkb:HSP40
BAG family proteins
co-chaperones
|
|
gptkbp:locale
|
gptkb:endoplasmic_reticulum
gptkb:nucleus
mitochondria
cytosol
|
|
gptkbp:memberOf
|
heat shock protein family
|
|
gptkbp:molecularWeight
|
approximately 70 kDa
|
|
gptkbp:proteinFamily
|
gptkb:HSPA
|
|
gptkbp:regulates
|
gptkb:heat_shock_factor_1_(HSF1)
|
|
gptkbp:requires
|
cell survival under stress
|
|
gptkbp:role
|
gptkb:immune_response
gptkb:cellular_stress_response
apoptosis regulation
protein homeostasis
|
|
gptkbp:significance
|
gptkb:cancer
neurodegenerative diseases
autoimmune diseases
|
|
gptkbp:structure
|
C-terminal substrate-binding domain
N-terminal ATPase domain
linker region
|
|
gptkbp:usedAs
|
biomarker for stress
therapeutic target
|
|
gptkbp:bfsParent
|
gptkb:CHIP
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HSP70
|