Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:Heat_shock_protein_70
|
| gptkbp:assistsIn |
antigen presentation
degradation of misfolded proteins refolding denatured proteins |
| gptkbp:conservedIn |
all domains of life
|
| gptkbp:contains |
ATPase domain
substrate-binding domain |
| gptkbp:example |
gptkb:HSPA1A
gptkb:HSPA1B gptkb:HSPA8 |
| gptkbp:firstDescribed |
1970s
|
| gptkbp:foundIn |
gptkb:Bacteria
archaea eukaryotes |
| gptkbp:function |
protein folding
assists in protein transport across membranes molecular chaperone prevention of protein aggregation |
| https://www.w3.org/2000/01/rdf-schema#label |
HSP70
|
| gptkbp:inducedBy |
heat shock
cellular stress |
| gptkbp:inhibitedBy |
gptkb:PES
gptkb:VER-155008 |
| gptkbp:interactsWith |
gptkb:HSP40
BAG family proteins co-chaperones |
| gptkbp:locale |
gptkb:endoplasmic_reticulum
gptkb:nucleus mitochondria cytosol |
| gptkbp:memberOf |
heat shock protein family
|
| gptkbp:molecularWeight |
approximately 70 kDa
|
| gptkbp:proteinFamily |
gptkb:HSPA
|
| gptkbp:regulates |
gptkb:heat_shock_factor_1_(HSF1)
|
| gptkbp:requires |
cell survival under stress
|
| gptkbp:role |
immune response
apoptosis regulation cellular stress response protein homeostasis |
| gptkbp:significance |
gptkb:cancer
neurodegenerative diseases autoimmune diseases |
| gptkbp:structure |
C-terminal substrate-binding domain
N-terminal ATPase domain linker region |
| gptkbp:usedAs |
biomarker for stress
therapeutic target |
| gptkbp:bfsParent |
gptkb:HSP_gene_family
gptkb:CHIP |
| gptkbp:bfsLayer |
6
|