G protein-coupled receptor (GPCR)

URI: https://gptkb.org/entity/G_protein-coupled_receptor_(GPCR)

GPTKB entity

Statements (69)

Predicate	Object
gptkbp:instanceOf	gptkb:protein cell surface receptor
gptkbp:activatedBy	gptkb:G_protein-coupled_receptor
gptkbp:alternativeName	7TM receptor heptahelical receptor seven-transmembrane receptor
gptkbp:binds	ligand
gptkbp:database	gptkb:GPCRdb gptkb:IUPHAR/BPS_Guide_to_Pharmacology
gptkbp:discoveredBy	gptkb:Robert_J._Lefkowitz gptkb:Brian_Kobilka
gptkbp:encodedBy	GPCR genes
gptkbp:example	gptkb:receptor_tyrosine_kinase gptkb:angiotensin_receptor gptkb:beta-adrenergic_receptor gptkb:glucagon_receptor gptkb:muscarinic_acetylcholine_receptor gptkb:olfactory_receptor gptkb:rhodopsin dopamine receptor opioid antihistamine frizzled receptor smoothened receptor
gptkbp:foundIn	eukaryotes
gptkbp:function	signal transduction
https://www.w3.org/2000/01/rdf-schema#label	G protein-coupled receptor (GPCR)
gptkbp:involvedIn	gptkb:DVD immune response taste smell neurotransmission hormone response
gptkbp:locale	gptkb:cell_membrane
gptkbp:mechanismOfAction	activation of intracellular signaling pathways conformational change upon ligand binding
gptkbp:modulatedBy	antagonist agonist allosteric modulator inverse agonist
gptkbp:NobelPrizeYear	gptkb:2012_Nobel_Prize_in_Chemistry
gptkbp:numberOfGenes	over 800
gptkbp:regulates	phosphorylation arrestin binding desensitization internalization
gptkbp:relatedTo	gptkb:IP3 gptkb:adenylate_cyclase gptkb:cAMP gptkb:DAG gptkb:phospholipase_C GTPase activity heterotrimeric G proteins calcium signaling second messenger systems Gα, Gβ, Gγ subunits
gptkbp:significance	gptkb:cancer cardiovascular diseases neurological disorders metabolic diseases psychiatric disorders
gptkbp:structure	seven transmembrane alpha helices
gptkbp:subclassOf	gptkb:Class_A_(Rhodopsin-like) gptkb:Class_B_(Secretin_receptor_family) gptkb:Class_C_(Metabotropic_glutamate/pheromone) gptkb:Class_F_(Frizzled/Smoothened)
gptkbp:target	pharmaceutical drugs
gptkbp:bfsParent	gptkb:G_protein-coupled_receptor
gptkbp:bfsLayer	5