|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:activatedBy
|
gptkb:phospholipase_C
|
|
gptkbp:alternativeName
|
gptkb:HRH1
H1R
histamine_H1_receptor
histamine_receptor
|
|
gptkbp:binds
|
gptkb:histamine
|
|
gptkbp:discoveredBy
|
1960s
|
|
gptkbp:encodedBy
|
gptkb:HRH1_gene
gptkb:HRH2_gene
gptkb:HRH3_gene
gptkb:HRH4_gene
|
|
gptkbp:enemyOf
|
gptkb:cetirizine
gptkb:loratadine
gptkb:promethazine
gptkb:histamine
gptkb:azelastine
gptkb:fexofenadine
diphenhydramine
chlorpheniramine
|
|
gptkbp:Entrez_Gene_ID
|
3269
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skin
brain
heart
liver
endothelial cells
smooth muscle
|
|
gptkbp:foundIn
|
mammals
other vertebrates
|
|
gptkbp:function
|
increases vascular permeability
binds histamine
involved in neurotransmission
causes smooth muscle contraction
induces vasodilation
mediates allergic response
|
|
gptkbp:improves
|
intracellular calcium
|
|
gptkbp:involvedIn
|
immune response
gastric acid secretion
allergic reaction
neurotransmission
|
|
gptkbp:length
|
487 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3p25
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:MIM
|
607156
|
|
gptkbp:molecularWeight
|
56 kDa
|
|
gptkbp:OMIM
|
142704
|
|
gptkbp:PDB
|
3RZE
7DFL
|
|
gptkbp:RefSeq
|
NM_000861
|
|
gptkbp:relatedTo
|
gptkb:histamine_H3_receptor
histamine H2 receptor
histamine H4 receptor
|
|
gptkbp:subclassOf
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:subspecies
|
gptkb:H1_receptor
gptkb:H2_receptor
gptkb:H3_receptor
gptkb:H4_receptor
|
|
gptkbp:target
|
antihistamines
allergy medications
sedative drugs
|
|
gptkbp:type
|
Gq/11 protein
|
|
gptkbp:UniProtID
|
gptkb:P35367
|
|
gptkbp:bfsParent
|
gptkb:Zyrtec
gptkb:G_protein-coupled_receptor
gptkb:G_protein-coupled_receptors
gptkb:Clarinex
gptkb:Pataday
gptkb:Zaditen
|
|
gptkbp:bfsLayer
|
5
|