|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:alternativeName
|
morphinan
opioid_analgesic
opioid_antagonist
opioid_receptor
opioid_receptor_antagonist
synthetic_opioid
|
|
gptkbp:binds
|
gptkb:enkephalins
opioids
dynorphins
endorphins
|
|
gptkbp:CASNumber
|
482-87-1
|
|
gptkbp:chemicalFormula
|
C16H21N
|
|
gptkbp:contains_functional_group
|
amphetamine
aromatic ring
|
|
gptkbp:core_structure_for
|
many opioid drugs
|
|
gptkbp:discoveredBy
|
1970s
|
|
gptkbp:encodedBy
|
gptkb:OPRD1_gene
gptkb:OPRK1_gene
gptkb:OPRL1_gene
gptkb:OPRM1_gene
|
|
gptkbp:enemyOf
|
gptkb:methadone
gptkb:oxycodone
gptkb:codeine
gptkb:morphine
gptkb:naloxone
gptkb:naltrexone
amphetamine
fentanyl
|
|
gptkbp:expressedIn
|
gptkb:spinal_cord
brain
gastrointestinal tract
immune cells
|
|
gptkbp:foundIn
|
gptkb:opioid_analgesics
central nervous system
peripheral nervous system
|
|
gptkbp:function
|
gptkb:award
addiction
pain modulation
respiratory depression
|
|
gptkbp:IUPACName
|
9,13,14,17-tetrahydro-7,8-didehydro-4H-dibenzo[a,g]quinolizine
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:mechanismOfAction
|
inhibits adenylate cyclase
activates potassium channels
inhibits calcium channels
|
|
gptkbp:modulatedBy
|
phosphorylation
desensitization
internalization
|
|
gptkbp:molecularWeight
|
227.34 g/mol
|
|
gptkbp:parent
|
gptkb:dextromethorphan
gptkb:codeine
gptkb:morphine
gptkb:levorphanol
|
|
gptkbp:relatedTo
|
substance abuse
opioid dependence
opioid tolerance
opioid withdrawal
|
|
gptkbp:structureType
|
tetracyclic
|
|
gptkbp:subspecies
|
gptkb:nociceptin_receptor
gptkb:delta-opioid_receptor
gptkb:kappa-opioid_receptor
gptkb:mu-opioid_receptor
|
|
gptkbp:target
|
analgesic drugs
antidiarrheal drugs
antitussive drugs
|
|
gptkbp:bfsParent
|
gptkb:G_protein-coupled_receptor
gptkb:G_protein-coupled_receptors
|
|
gptkbp:bfsLayer
|
5
|