Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
gptkb:G_protein-coupled_receptor_(GPCR)
|
| gptkbp:amendedBy |
gptkb:adenylate_cyclase
gptkb:phospholipase_C ion channels phosphodiesterases |
| gptkbp:discoveredIn |
1970s
|
| gptkbp:dissociatesFrom |
Gβγ dimer upon activation
|
| gptkbp:encodedBy |
gptkb:GNA_genes
|
| gptkbp:function |
hydrolyzes GTP
binds guanine nucleotides (GDP and GTP) |
| https://www.w3.org/2000/01/rdf-schema#label |
Gα subunit
|
| gptkbp:interactsWith |
gptkb:Gβγ_dimer
|
| gptkbp:involvedIn |
signal transduction
|
| gptkbp:location |
cytoplasmic side of plasma membrane
|
| gptkbp:partOf |
heterotrimeric G protein
|
| gptkbp:regulates |
second messenger systems
|
| gptkbp:returnsToInactiveStateBy |
hydrolyzing GTP to GDP
|
| gptkbp:significance |
mutations can cause disease
target for drug development |
| gptkbp:structure |
contains helical domain
contains GTPase domain |
| gptkbp:subspecies |
gptkb:Gα12/13
gptkb:Gαq Gαi Gαs |
| gptkbp:bfsParent |
gptkb:G_protein-coupled_receptor
|
| gptkbp:bfsLayer |
5
|