|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alias
|
gptkb:K-Ras
gptkb:Kirsten_rat_sarcoma_viral_oncogene_homolog
gptkb:RASK2
C-K-RAS
|
|
gptkbp:alternativeSplicing
|
gptkb:KRas4A
gptkb:KRas4B
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Weinberg
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:KRAS_gene
|
|
gptkbp:form
|
GTP-bound
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
signal transduction
GTPase activity
|
|
gptkbp:gene
|
gptkb:KRAS
|
|
gptkbp:HGNC_ID
|
6407
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GTPase KRas
|
|
gptkbp:inactive_form
|
GDP-bound
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
12p12.1
|
|
gptkbp:member
|
gptkb:small_GTPase_family
gptkb:RAS_superfamily
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutation_hotspot
|
codon 12
codon 13
codon 61
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
colorectal cancer
pancreatic cancer
|
|
gptkbp:orthologInMouse
|
gptkb:Kras
|
|
gptkbp:PDB
|
gptkb:4OBE
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
gptkb:MAPK_pathway
gptkb:PI3K-AKT_pathway
apoptosis
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:target
|
gptkb:adagrasib
gptkb:sotorasib
cancer therapeutics
|
|
gptkbp:UniProtID
|
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:Kras_(mouse)
gptkb:v-Ki-ras2_Kirsten_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:bfsLayer
|
7
|