|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
K-RasB
K-Ras 4B
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:discoveredBy
|
Chandra et al.
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:encodedBy
|
gptkb:KRAS_gene
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:hasIsoform
|
gptkb:KRas4A
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KRas4B
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
cell signaling
|
|
gptkbp:length
|
188 amino acids
|
|
gptkbp:locale
|
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
chromosome 12p12.1
|
|
gptkbp:memberOf
|
gptkb:Ras_protein_family
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
colorectal cancer
pancreatic cancer
codon 12
codon 13
codon 61
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:4OBE
6OIM
|
|
gptkbp:postTranslationalModification
|
farnesylation
phosphorylation
carboxymethylation
|
|
gptkbp:regulates
|
gptkb:MAPK_pathway
gptkb:PI3K-AKT_pathway
RAF-MEK-ERK pathway
|
|
gptkbp:significance
|
tumor suppressor
|
|
gptkbp:structure
|
contains G domain
contains hypervariable region
|
|
gptkbp:subcellularLocation
|
inner leaflet of plasma membrane
|
|
gptkbp:target
|
gptkb:adagrasib
gptkb:sotorasib
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:GTPase_KRas
gptkb:KRas
|
|
gptkbp:bfsLayer
|
8
|