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gptkbp:instanceOf
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superfamily
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gptkbp:abbreviation
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gptkb:Ras_GTPases
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gptkbp:activeState
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GTP-bound
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gptkbp:composedOf
|
small GTPases
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gptkbp:database
|
gptkb:InterPro:_IPR001806
gptkb:PROSITE:_PS51421
gptkb:Pfam:_PF00071
gptkb:SCOP:_1q21
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gptkbp:discoveredBy
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biochemical studies in the 1980s
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gptkbp:domain
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gptkb:GTP-binding_domain
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gptkbp:evolvesFrom
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ancient eukaryotic ancestor
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gptkbp:foundIn
|
eukaryotes
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gptkbp:function
|
signal transduction
vesicle trafficking
regulation of cell differentiation
regulation of cell growth
nuclear transport
regulation of cytoskeletal organization
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gptkbp:GO_term
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GO:0003924 (GTPase activity)
GO:0005525 (GTP binding)
GO:0007264 (small GTPase mediated signal transduction)
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gptkbp:hasMember
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gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
gptkb:Ran
gptkb:Arf1
gptkb:Rab5
gptkb:RhoA
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAS superfamily
|
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gptkbp:inactiveState
|
GDP-bound
|
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gptkbp:includes
|
gptkb:Arf_family
gptkb:Rab_family
gptkb:Ran_family
gptkb:Rho_family
gptkb:Ras_family
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gptkbp:memberOf
|
gptkb:GTPase_superfamily
|
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gptkbp:mutationAssociatedWith
|
gptkb:cancer
|
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gptkbp:regulates
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gptkb:guanine_nucleotide_dissociation_inhibitors_(GDIs)
GTPase-activating proteins (GAPs)
cell proliferation
cell survival
gene expression
cell migration
guanine nucleotide exchange factors (GEFs)
cell polarity
membrane trafficking
|
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gptkbp:relatedTo
|
oncogenesis
|
|
gptkbp:structure
|
conserved G domain
|
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gptkbp:bfsParent
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gptkb:RAS
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gptkbp:bfsLayer
|
4
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