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gptkbp:instanceOf
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gptkb:gene
tumor suppressor
|
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gptkbp:alias
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gptkb:c-Fos
Finkel-Biskis-Jinkins murine osteogenic sarcoma virus oncogene homolog
AP-1 transcription factor subunit
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gptkbp:associatedWith
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gptkb:cancer
|
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gptkbp:chromosomeArm
|
14q24.3
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gptkbp:discoveredIn
|
1983
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gptkbp:encodes
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gptkb:c-Fos_protein
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gptkbp:Entrez_Gene_ID
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gptkb:ENSG00000170345
2353
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gptkbp:expressedIn
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gptkb:nucleus
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gptkbp:formsComplexWith
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gptkb:JUNB
JUND
JUN proto-oncogene
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gptkbp:foundIn
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gptkb:Homo_sapiens
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gptkbp:function
|
transcription factor
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gptkbp:HGNC_ID
|
HGNC:3796
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|
https://www.w3.org/2000/01/rdf-schema#label
|
FOS proto-oncogene
|
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gptkbp:length
|
380 amino acids
|
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gptkbp:locatedOnChromosome
|
14
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gptkbp:memberOf
|
AP-1 transcription factor complex
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gptkbp:molecularWeight
|
~62 kDa
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gptkbp:mutationAssociatedWith
|
osteosarcoma
various cancers
|
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gptkbp:orthologIn
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gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
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gptkbp:proteinFamily
|
basic leucine zipper (bZIP) domain
|
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gptkbp:regulates
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gptkb:cyclin_D1
gptkb:TNF-alpha
gptkb:transformation
gptkb:IL-2
gptkb:BCL2
gptkb:CD44
gptkb:MMP1
gptkb:MMP9
gptkb:VEGF
gptkb:FASL
apoptosis
cell proliferation
differentiation
cytokines
growth factors
UV radiation
stress signals
oncogenic signals
c-myc
serum stimulation
binds DNA at AP-1 sites
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gptkbp:UniProtID
|
P01100
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gptkbp:bfsParent
|
gptkb:FOS_gene
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gptkbp:bfsLayer
|
8
|