|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:Proto-oncogene_c-Fos
gptkb:AP-1_transcription_factor_subunit_c-Fos
|
|
gptkbp:associatedWith
|
gptkb:cancer
osteosarcoma virus
|
|
gptkbp:degradedBy
|
gptkb:proteasome
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:FOS_gene
|
|
gptkbp:Entrez_Gene_ID
|
2353
|
|
gptkbp:expressedIn
|
brain
liver
various tissues
|
|
gptkbp:formsComplexWith
|
gptkb:AP-1_transcription_factor
c-Jun protein
|
|
gptkbp:formsHeterodimerWith
|
gptkb:Jun_family_proteins
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
transcription factor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-Fos protein
|
|
gptkbp:inducedBy
|
cytokines
growth factors
UV radiation
neuronal stimulation
serum stimulation
|
|
gptkbp:involvedIn
|
apoptosis
cell proliferation
differentiation
neuronal activity
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_14q24.3
|
|
gptkbp:marking
|
neuronal activation
|
|
gptkbp:molecularWeight
|
~62 kDa
|
|
gptkbp:OMIM
|
164810
|
|
gptkbp:orthologIn
|
many vertebrates
|
|
gptkbp:PDB
|
1FOS
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:regulates
|
gptkb:MAPK_pathway
gene expression
growth factors
stress signals
|
|
gptkbp:role
|
gptkb:synaptic_plasticity
cell cycle regulation
inflammation
immune response
learning and memory
oncogenesis
bone development
|
|
gptkbp:structure
|
basic leucine zipper (bZIP) domain
|
|
gptkbp:UniProtID
|
P01100
|
|
gptkbp:bfsParent
|
gptkb:FOS_gene
gptkb:c-fos_gene
|
|
gptkbp:bfsLayer
|
8
|