|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
gptkb:cancer
age-related macular degeneration
diabetic retinopathy
|
|
gptkbp:category
|
growth factor
signaling molecule
cytokine
|
|
gptkbp:discoveredBy
|
gptkb:Napoleone_Ferrara
|
|
gptkbp:fullName
|
Vascular Endothelial Growth Factor
|
|
gptkbp:function
|
increases vascular permeability
stimulates angiogenesis
|
|
gptkbp:gene
|
gptkb:VEGFA
gptkb:VEGFB
gptkb:PGF
VEGFC
VEGFD
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VEGF
|
|
gptkbp:locatedOnChromosome
|
6p21.1 (VEGFA)
|
|
gptkbp:medicalUse
|
targeted in anti-angiogenic therapy
|
|
gptkbp:OMIM
|
192240 (VEGFA)
|
|
gptkbp:recipient
|
gptkb:VEGFR1
gptkb:VEGFR2
gptkb:VEGFR3
|
|
gptkbp:regulates
|
upregulated by hypoxia
regulated by HIF-1
|
|
gptkbp:structure
|
homodimeric glycoprotein
|
|
gptkbp:target
|
gptkb:bevacizumab
gptkb:aflibercept
gptkb:ranibizumab
|
|
gptkbp:UniProtID
|
P15692 (VEGFA)
|
|
gptkbp:bfsParent
|
gptkb:VEGFA
gptkb:VEGFA_gene
gptkb:Clear_cell_adenocarcinoma_of_the_kidney
gptkb:advanced_renal_cell_carcinoma
|
|
gptkbp:bfsLayer
|
6
|