Enhancer of zeste homolog 2

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:gene
gptkbp:alias	gptkb:EZH2 gptkb:ENX1 gptkb:KMT6
gptkbp:associatedWith	gptkb:leukemia gptkb:cancer prostate cancer
gptkbp:catalyzes	trimethylation of histone H3 at lysine 27 (H3K27me3)
gptkbp:component	gptkb:Polycomb_Repressive_Complex_2_(PRC2) nucleoplasm
gptkbp:encodedBy	gptkb:EZH2_gene
gptkbp:Entrez_Gene_ID	2146
gptkbp:enzymeCommissionNumber	2.1.1.43
gptkbp:expressedIn	gptkb:nucleus
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	histone methyltransferase histone-lysine N-methyltransferase activity
gptkbp:geneType	protein-coding
gptkbp:GOProcess	regulation of transcription, DNA-templated chromatin silencing
gptkbp:HGNC_ID	3527
gptkbp:inhibitedBy	gptkb:GSK126 gptkb:tazemetostat
gptkbp:interactsWith	gptkb:EED gptkb:JARID2 gptkb:SUZ12
gptkbp:involvedIn	cell proliferation stem cell maintenance epigenetic regulation tumorigenesis
gptkbp:locatedOnChromosome	7q36.1
gptkbp:memberOf	gptkb:Polycomb-group_family
gptkbp:molecularWeight	85 kDa
gptkbp:mutationAssociatedWith	gptkb:Weaver_syndrome
gptkbp:OMIM	601573
gptkbp:orthologIn	gptkb:Drosophila_melanogaster_(E(z))
gptkbp:PDB	gptkb:5HYN
gptkbp:phosphorylates	gptkb:AKT1 gptkb:CDK1
gptkbp:regulates	gene silencing
gptkbp:target	gptkb:CRISPR/Cas9 gptkb:RNA_interference small molecule inhibitors
gptkbp:UniProtID	gptkb:Q15910
gptkbp:bfsParent	gptkb:EZH2
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Enhancer of zeste homolog 2