Enhancer of zeste homolog 2

URI: https://gptkb.org/entity/Enhancer_of_zeste_homolog_2
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alias gptkb:EZH2
gptkb:ENX1
gptkb:KMT6
gptkbp:associatedWith gptkb:cancer
leukemia
prostate cancer
gptkbp:catalyzes trimethylation of histone H3 at lysine 27 (H3K27me3)
gptkbp:component gptkb:Polycomb_Repressive_Complex_2_(PRC2)
nucleoplasm
gptkbp:encodedBy gptkb:EZH2_gene
gptkbp:Entrez_Gene_ID 2146
gptkbp:enzymeCommissionNumber 2.1.1.43
gptkbp:expressedIn gptkb:nucleus
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function histone methyltransferase
histone-lysine N-methyltransferase activity
gptkbp:geneType protein-coding
gptkbp:GOProcess regulation of transcription, DNA-templated
chromatin silencing
gptkbp:HGNC_ID 3527
https://www.w3.org/2000/01/rdf-schema#label Enhancer of zeste homolog 2
gptkbp:inhibitedBy gptkb:GSK126
gptkb:tazemetostat
gptkbp:interactsWith gptkb:EED
gptkb:JARID2
gptkb:SUZ12
gptkbp:involvedIn cell proliferation
stem cell maintenance
epigenetic regulation
tumorigenesis
gptkbp:locatedOnChromosome 7q36.1
gptkbp:memberOf gptkb:Polycomb-group_family
gptkbp:molecularWeight 85 kDa
gptkbp:mutationAssociatedWith gptkb:Weaver_syndrome
gptkbp:OMIM 601573
gptkbp:orthologIn gptkb:Drosophila_melanogaster_(E(z))
gptkbp:PDB gptkb:5HYN
gptkbp:phosphorylates gptkb:AKT1
gptkb:CDK1
gptkbp:regulates gene silencing
gptkbp:target gptkb:CRISPR/Cas9
gptkb:RNA_interference
small molecule inhibitors
gptkbp:UniProtID gptkb:Q15910
gptkbp:bfsParent gptkb:EZH2
gptkbp:bfsLayer 7