|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:WVS
gptkb:ENX1
gptkb:KMT6
|
|
gptkbp:amendedBy
|
histone H3 lysine 27 (H3K27)
|
|
gptkbp:associatedWith
|
gptkb:cancer
leukemia
prostate cancer
|
|
gptkbp:component
|
gptkb:Polycomb_Repressive_Complex_2_(PRC2)
|
|
gptkbp:discoveredBy
|
studies of Drosophila Polycomb group proteins
|
|
gptkbp:encodes
|
gptkb:Enhancer_of_zeste_homolog_2_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000106462
2146
|
|
gptkbp:expressedIn
|
gptkb:nucleus
|
|
gptkbp:fullName
|
gptkb:Enhancer_of_zeste_homolog_2
|
|
gptkbp:function
|
histone methyltransferase
|
|
gptkbp:GO_term
|
gptkb:GO:0006355_(regulation_of_transcription,_DNA-templated)
GO:0005634 (nucleus)
GO:0016571 (histone methylation)
|
|
gptkbp:HGNC_ID
|
gptkb:EZH2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EZH2 gene
|
|
gptkbp:inhibitedBy
|
gptkb:EPZ-6438
gptkb:GSK126
gptkb:tazemetostat
|
|
gptkbp:involvedIn
|
cell proliferation
stem cell maintenance
epigenetic regulation
|
|
gptkbp:locatedOnChromosome
|
7q36.1
|
|
gptkbp:methylates
|
gptkb:H3K27
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Weaver_syndrome
gain-of-function
loss-of-function
myeloid malignancies
|
|
gptkbp:OMIM
|
601573
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Drosophila_melanogaster
Mus musculus (mouse)
|
|
gptkbp:pathway
|
PRC2-mediated gene silencing
epigenetic regulation of gene expression
|
|
gptkbp:proteinFamily
|
SET domain-containing proteins
|
|
gptkbp:regulates
|
differentiation
gene silencing
cell cycle
tumor progression
developmental gene expression
|
|
gptkbp:target
|
gptkb:EPZ-6438
gptkb:GSK126
gptkb:tazemetostat
|
|
gptkbp:UniProtID
|
gptkb:Q15910
|
|
gptkbp:bfsParent
|
gptkb:EZH2
|
|
gptkbp:bfsLayer
|
7
|