Polycomb Repressive Complex 2 (PRC2)
GPTKB entity
Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:amendedBy |
chromatin structure
|
| gptkbp:associatedWith |
transcriptional repression
|
| gptkbp:catalyzes |
trimethylation of histone H3 at lysine 27 (H3K27me3)
|
| gptkbp:component |
gptkb:EED
gptkb:RBBP7 gptkb:EZH2 gptkb:AEBP2 gptkb:JARID2 gptkb:SUZ12 gptkb:RBBP4 |
| gptkbp:discoveredIn |
gptkb:Drosophila_melanogaster
|
| gptkbp:function |
epigenetic gene silencing
|
| gptkbp:gene |
gptkb:EED
gptkb:EZH2 gptkb:SUZ12 |
| https://www.w3.org/2000/01/rdf-schema#label |
Polycomb Repressive Complex 2 (PRC2)
|
| gptkbp:inhibitedBy |
EZH2 inhibitors
|
| gptkbp:involvedIn |
gptkb:X-chromosome_inactivation
cancer progression stem cell pluripotency |
| gptkbp:locale |
gptkb:nucleus
|
| gptkbp:orthologIn |
gptkb:Polycomb_group_proteins
|
| gptkbp:regulates |
developmental genes
|
| gptkbp:relatedTo |
gptkb:Polycomb_Repressive_Complex_1_(PRC1)
|
| gptkbp:requires |
embryonic development
|
| gptkbp:target |
long non-coding RNAs
|
| gptkbp:bfsParent |
gptkb:EZH2
gptkb:Polycomb-group_(PcG)_protein_family |
| gptkbp:bfsLayer |
7
|