|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:WVS
gptkb:ENX1
gptkb:KMT6
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:catalyzes
|
trimethylation of histone H3 at lysine 27 (H3K27me3)
|
|
gptkbp:component
|
gptkb:Polycomb_Repressive_Complex_2_(PRC2)
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodedBy
|
gptkb:EZH2_gene
|
|
gptkbp:Entrez_Gene_ID
|
2146
|
|
gptkbp:enzymeCommissionNumber
|
2.1.1.43
|
|
gptkbp:expressedIn
|
gptkb:nucleus
various tissues
|
|
gptkbp:fullName
|
gptkb:Enhancer_of_zeste_homolog_2
|
|
gptkbp:function
|
histone methyltransferase
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
3527
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EZH2
|
|
gptkbp:inhibitedBy
|
gptkb:miR-101
gptkb:miR-214
gptkb:miR-26a
|
|
gptkbp:interactsWith
|
gptkb:EED
gptkb:AEBP2
gptkb:JARID2
gptkb:SUZ12
|
|
gptkbp:locatedOnChromosome
|
7q36.1
|
|
gptkbp:memberOf
|
gptkb:Polycomb-group_(PcG)_family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Weaver_syndrome
myeloid malignancies
|
|
gptkbp:OMIM
|
601573
|
|
gptkbp:orthologInMouse
|
gptkb:Ezh2
|
|
gptkbp:overexpressedIn
|
gptkb:cancer
leukemia
melanoma
prostate cancer
|
|
gptkbp:PDB
|
gptkb:5HYN
5IJ7
|
|
gptkbp:phosphorylates
|
gptkb:AKT
gptkb:CDK1
|
|
gptkbp:RefSeq
|
NM_004456
|
|
gptkbp:regulates
|
cell proliferation
differentiation
gene silencing
stem cell maintenance
|
|
gptkbp:target
|
gptkb:EPZ-6438
gptkb:GSK126
gptkb:tazemetostat
|
|
gptkbp:UniProtID
|
gptkb:Q15910
|
|
gptkbp:bfsParent
|
gptkb:Ezh6
|
|
gptkbp:bfsLayer
|
6
|