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gptkbp:instanceOf
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gptkb:gene
|
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gptkbp:alternativeName
|
URG
epidermal growth factor precursor
|
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gptkbp:associatedWith
|
gptkb:cancer
kidney disease
wound healing
gastric cancer
glioma
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gptkbp:biologicalProcess
|
cell differentiation
cell proliferation
|
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gptkbp:cellularComponent
|
extracellular region
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gptkbp:discoveredBy
|
gptkb:Stanley_Cohen
|
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gptkbp:discoveredIn
|
1983
|
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gptkbp:encodes
|
epidermal growth factor protein
|
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gptkbp:Entrez_Gene_ID
|
1950
ENSG00000138798
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gptkbp:expressedIn
|
epithelial tissues
|
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gptkbp:fullName
|
epidermal growth factor gene
|
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gptkbp:function
|
stimulates cell growth, proliferation, and differentiation
|
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gptkbp:geneType
|
protein-coding
|
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gptkbp:GO:molecularFunction
|
growth factor activity
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gptkbp:hasPolymorphism
|
rs4444903
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gptkbp:hasTranscriptVariant
|
multiple
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gptkbp:HGNC_ID
|
3229
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EGF gene
|
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gptkbp:interactsWith
|
gptkb:EGFR
gptkb:ERBB3
gptkb:ERBB2
gptkb:ERBB4
|
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gptkbp:length
|
1206 amino acids (precursor)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4
4q25
|
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gptkbp:locusType
|
4q25
|
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gptkbp:mRNAReferenceSequence
|
NM_001963
|
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gptkbp:mutationAssociatedWith
|
may alter susceptibility to cancer
|
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gptkbp:OMIM
|
131530
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologInMouse
|
Egf
|
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gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
gptkb:ErbB_signaling_pathway
|
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gptkbp:product
|
gptkb:EGF
|
|
gptkbp:proteinReferenceSequence
|
NP_001954
|
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gptkbp:referenceGenome
|
gptkb:GRCh38
|
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gptkbp:regulates
|
gptkb:EGFR_signaling_pathway
|
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gptkbp:significance
|
polymorphisms associated with cancer risk
|
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gptkbp:symbol
|
gptkb:EGF
|
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gptkbp:UniProtID
|
P01133
|
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gptkbp:bfsParent
|
gptkb:EGF
gptkb:epidermal_growth_factor_(EGF)
gptkb:epidermal_growth_factor
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gptkbp:bfsLayer
|
7
|