|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CYP2D
gptkb:CYP2D6P
gptkb:CYP2D7AP
gptkb:P450DB1
|
|
gptkbp:associatedWith
|
gptkb:codeine
gptkb:tamoxifen
gptkb:adverse_drug_reaction
beta blockers
opioids
antipsychotics
antidepressants
poor metabolizer phenotype
ultrarapid metabolizer phenotype
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000100197
1565
|
|
gptkbp:enzyme
|
true
|
|
gptkbp:expressedIn
|
gptkb:small_intestine
brain
liver
|
|
gptkbp:fullName
|
gptkb:cytochrome_P450_family_2_subfamily_D_member_6
|
|
gptkbp:function
|
drug metabolism
oxidation of xenobiotics
|
|
gptkbp:gene
|
gptkb:CYP2D6
|
|
gptkbp:hasClinicalAnnotation
|
gptkb:PharmGKB:PA128
CPIC guideline for codeine
|
|
gptkbp:hasPolymorphism
|
true
|
|
gptkbp:hasTranscriptVariant
|
gptkb:NM_000106.5
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:3113
|
|
gptkbp:involvedIn
|
hydroxylation
oxidative dealkylation
phase I drug metabolism
|
|
gptkbp:isClinicallyActionable
|
true
|
|
gptkbp:isPharmacogene
|
true
|
|
gptkbp:isProteinCoding
|
true
|
|
gptkbp:isPseudogene
|
false
|
|
gptkbp:locatedOnChromosome
|
22
|
|
gptkbp:locusType
|
gptkb:22q13.2
|
|
gptkbp:memberOf
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:numberOfExons
|
9
|
|
gptkbp:OMIM
|
124030
|
|
gptkbp:orthologInMouse
|
gptkb:Cyp2d1
gptkb:Cyp2d22
|
|
gptkbp:product
|
gptkb:cytochrome_P450_2D6
|
|
gptkbp:proteinFamily
|
gptkb:CYP2D
|
|
gptkbp:RefSeq
|
gptkb:NM_000106
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:target
|
pharmacogenetic testing
|
|
gptkbp:UniProtID
|
P10635
|
|
gptkbp:bfsParent
|
gptkb:E2F1
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HGNC:3113
|