Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activatedBy |
gptkb:Ras
gptkb:receptor_tyrosine_kinases |
| gptkbp:catalyzes |
phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2)
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
autoimmune diseases insulin resistance |
| gptkbp:encodedBy |
gptkb:PIK3CA
gptkb:PIK3CB gptkb:PIK3CD |
| gptkbp:hasRegulatorySubunit |
gptkb:p55γ
gptkb:p85β gptkb:p85α |
| https://www.w3.org/2000/01/rdf-schema#label |
Class IA PI3K
|
| gptkbp:inhibitedBy |
gptkb:LY294002
gptkb:wortmannin |
| gptkbp:involvedIn |
gptkb:PI3K/AKT_signaling_pathway
cell survival metabolism cell growth regulation |
| gptkbp:location |
gptkb:cytoplasm
gptkb:plasma_membrane |
| gptkbp:produces |
gptkb:phosphatidylinositol_3,4,5-trisphosphate_(PIP3)
|
| gptkbp:subunit |
gptkb:p110α
gptkb:p110δ gptkb:p110β |
| gptkbp:bfsParent |
gptkb:Class_I_PI3K
|
| gptkbp:bfsLayer |
5
|