|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:PI3K-beta
gptkb:p110β
gptkb:phosphoinositide-3-kinase_catalytic_subunit_beta
gptkb:PI3-kinase_p110-beta
|
|
gptkbp:associatedWith
|
gptkb:cancer
thrombosis
insulin resistance
|
|
gptkbp:discoveredBy
|
researchers in the 1990s
|
|
gptkbp:domain
|
gptkb:PI3K/PI4K_domain
kinase domain
C2 domain
helical domain
|
|
gptkbp:encodes
|
gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_beta_isoform
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000145675
5291
|
|
gptkbp:enzymeClassification
|
gptkb:EC_2.7.1.153
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
heart
many tissues
|
|
gptkbp:function
|
catalytic subunit of class IA PI3K
phosphorylates phosphoinositides
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
8975
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PIK3CB (p110β)
|
|
gptkbp:interactsWith
|
gptkb:RAS_proteins
G-protein coupled receptors
p85 regulatory subunit
|
|
gptkbp:involvedIn
|
gptkb:PI3K/AKT_signaling_pathway
cell proliferation
cell survival
cell growth
insulin signaling
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3
3q22.3
|
|
gptkbp:molecularWeight
|
122 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Pik3cb
|
|
gptkbp:phosphorylates
|
gptkb:phosphatidylinositol_4,5-bisphosphate_(PIP2)
|
|
gptkbp:produces
|
gptkb:phosphatidylinositol_3,4,5-trisphosphate_(PIP3)
|
|
gptkbp:regulates
|
activated by G-protein coupled receptors
activated by receptor tyrosine kinases
inhibited by PI3K inhibitors
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:target
|
PI3K inhibitors (e.g., TGX-221, AZD6482)
|
|
gptkbp:UniProtID
|
gptkb:P42338
|
|
gptkbp:bfsParent
|
gptkb:Class_I_PI3K
|
|
gptkbp:bfsLayer
|
5
|