|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:p85-beta
gptkb:phosphoinositide-3-kinase_regulatory_subunit_2
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:megalencephaly-polymicrogyria-polydactyly-hydrocephalus_syndrome_(MPPH)
|
|
gptkbp:component
|
gptkb:phosphoinositide_3-kinase_complex
|
|
gptkbp:domain
|
SH2 domain
SH3 domain
BCR homology domain
|
|
gptkbp:encodedBy
|
gptkb:PIK3R2_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000105647
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
|
|
gptkbp:function
|
phosphatidylinositol 3-kinase regulator activity
regulatory subunit of phosphoinositide 3-kinase (PI3K)
|
|
gptkbp:gene
|
gptkb:PIK3R2
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
signal transduction
cellular response to insulin stimulus
|
|
gptkbp:HGNC_ID
|
8980
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PIK3R2 (p85β)
|
|
gptkbp:interactsWith
|
gptkb:SHC1
gptkb:PIK3CA
gptkb:PIK3CB
gptkb:PIK3CD
gptkb:IRS1
|
|
gptkbp:involvedIn
|
gptkb:PI3K/AKT_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.1
|
|
gptkbp:molecularWeight
|
85 kDa
|
|
gptkbp:mutationAssociatedWith
|
causes developmental brain disorders
oncogenic potential
|
|
gptkbp:OMIM
|
603157
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:RefSeq
|
NM_005027
|
|
gptkbp:regulates
|
cell proliferation
cell survival
cell growth
cell migration
insulin signaling
PI3K catalytic activity
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
O00459
|
|
gptkbp:bfsParent
|
gptkb:Class_I_PI3K
|
|
gptkbp:bfsLayer
|
5
|