|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:PI3-kinase_p110-alpha
gptkb:p110_alpha
gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_alpha
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:PIK3CA-related_overgrowth_spectrum
gptkb:endometrial_cancer
colorectal cancer
|
|
gptkbp:discoveredBy
|
gptkb:Jean-François_Côté_(research_group)
|
|
gptkbp:encodes
|
gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_alpha_isoform
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000121879
5290
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
catalytic subunit of class IA PI3K
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
8975
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PIK3CA (p110α)
|
|
gptkbp:inhibitedBy
|
gptkb:alpelisib
gptkb:copanlisib
gptkb:idelalisib
gptkb:taselisib
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3
3q26.32
|
|
gptkbp:mutationAssociatedWith
|
germline mutation
somatic mutation
E542K
E545K
H1047R
high in breast cancer
high in colorectal cancer
high in endometrial cancer
|
|
gptkbp:OMIM
|
171834
|
|
gptkbp:orthologInMouse
|
gptkb:Pik3ca
|
|
gptkbp:partOf
|
gptkb:PI3K/AKT/mTOR_pathway
|
|
gptkbp:pathway
|
gptkb:mTOR_signaling_pathway
gptkb:PI3K/AKT_pathway
gptkb:EGFR_signaling_pathway
insulin signaling pathway
|
|
gptkbp:phosphorylates
|
PIP2 to PIP3
|
|
gptkbp:product
|
gptkb:p110α
|
|
gptkbp:regulates
|
cell proliferation
cell survival
metabolism
angiogenesis
cell growth
cell motility
|
|
gptkbp:significance
|
tumor suppressor
therapeutic target
diagnostic biomarker
|
|
gptkbp:target
|
targeted cancer therapy
|
|
gptkbp:UniProtID
|
gptkb:P42336
|
|
gptkbp:bfsParent
|
gptkb:Class_I_PI3K
|
|
gptkbp:bfsLayer
|
5
|