|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_gamma_isoform
gptkb:PI3-kinase_p110_gamma
gptkb:phosphoinositide-3-kinase_gamma
gptkb:PI3Kγ
gptkb:p110_gamma
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
inflammatory diseases
|
|
gptkbp:biologicalProcess
|
signal transduction
immune response
kinase activity
inflammatory response
chemotaxis
|
|
gptkbp:component
|
gptkb:class_IB_PI3K_complex
|
|
gptkbp:discoveredBy
|
researchers in the 1990s
|
|
gptkbp:encodes
|
gptkb:phosphoinositide-3-kinase_catalytic_subunit_gamma
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000105851
5294
|
|
gptkbp:expressedIn
|
gptkb:leukocytes
heart
endothelial cells
|
|
gptkbp:function
|
regulates immune cell function
catalyzes phosphorylation of phosphoinositides
involved in cell signaling
regulates inflammation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
8987
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PIK3CG (p110γ)
|
|
gptkbp:interactsWith
|
gptkb:G_protein_beta-gamma_subunits
gptkb:RAS_proteins
|
|
gptkbp:length
|
1102
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_7
|
|
gptkbp:molecularWeight
|
126 kDa
|
|
gptkbp:OMIM
|
602838
|
|
gptkbp:orthologInMouse
|
gptkb:Pik3cg
|
|
gptkbp:phosphorylates
|
phosphatidylinositol-4,5-bisphosphate
|
|
gptkbp:produces
|
phosphatidylinositol-3,4,5-trisphosphate
|
|
gptkbp:RefSeq
|
NM_002649
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:target
|
gptkb:IPI-549
AS-605240
CZC24832
PI3Kγ inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P48736
|
|
gptkbp:bfsParent
|
gptkb:Class_I_PI3K
|
|
gptkbp:bfsLayer
|
5
|