Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
sulfonylurea |
| gptkbp:administeredBy |
oral
|
| gptkbp:approvedBy |
1956
|
| gptkbp:ATCCode |
A10BB03
|
| gptkbp:CASNumber |
64-77-7
|
| gptkbp:contains_functional_group |
sulfonylurea group
|
| gptkbp:contraindication |
gptkb:diabetic_ketoacidosis
type 1 diabetes |
| gptkbp:discoveredBy |
gptkb:Marion_Merrell_Dow
|
| gptkbp:eliminationHalfLife |
4-8 hours
|
| gptkbp:excretion |
gptkb:kidney
|
| gptkbp:hasMolecularFormula |
C12H18N2O3S
|
| https://www.w3.org/2000/01/rdf-schema#label |
tolbutamide
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:mechanismOfAction |
stimulates insulin release
|
| gptkbp:meltingPoint |
127-128°C
|
| gptkbp:metabolism |
liver
|
| gptkbp:pregnancyCategory |
C (US)
|
| gptkbp:proteinBinding |
96%
|
| gptkbp:PubChem_CID |
gptkb:CHEMBL1082
5502 DB01124 |
| gptkbp:routeOfAdministration |
oral
|
| gptkbp:sideEffect |
gptkb:hypoglycemia
gastrointestinal upset allergic skin reactions |
| gptkbp:synonym |
Orinase
|
| gptkbp:UNII |
O4L1XPO44W
|
| gptkbp:usedFor |
gptkb:type_2_diabetes
|
| gptkbp:bfsParent |
gptkb:CYP2C9
|
| gptkbp:bfsLayer |
5
|