|
gptkbp:instanceOf
|
gptkb:drug
gptkb:sulfonylurea
|
|
gptkbp:administeredBy
|
oral
|
|
gptkbp:approvedBy
|
1956
|
|
gptkbp:ATCCode
|
A10BB03
|
|
gptkbp:CASNumber
|
64-77-7
|
|
gptkbp:contains_functional_group
|
sulfonylurea group
|
|
gptkbp:contraindication
|
gptkb:diabetic_ketoacidosis
type 1 diabetes
|
|
gptkbp:discoveredBy
|
gptkb:Marion_Merrell_Dow
|
|
gptkbp:eliminationHalfLife
|
4-8 hours
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:hasMolecularFormula
|
C12H18N2O3S
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
stimulates insulin release
|
|
gptkbp:meltingPoint
|
127-128°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
96%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1082
5502
DB01124
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:hypoglycemia
gastrointestinal upset
allergic skin reactions
|
|
gptkbp:synonym
|
Orinase
|
|
gptkbp:UNII
|
O4L1XPO44W
|
|
gptkbp:usedFor
|
gptkb:type_2_diabetes
|
|
gptkbp:bfsParent
|
gptkb:CYP2C9
gptkb:Cyp2c11
gptkb:Sulfonylureas
gptkb:P07014
|
|
gptkbp:bfsLayer
|
8
|
|
http://www.w3.org/2000/01/rdf-schema#label
|
tolbutamide
|