|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:availableOn
|
gptkb:tablet
capsule
injection
gel
|
|
gptkbp:cause
|
hypertension
bronchospasm in asthmatics
fluid retention
|
|
gptkbp:contraindication
|
gptkb:peptic_ulcer_disease
chronic kidney disease
aspirin allergy
third trimester of pregnancy
|
|
gptkbp:discoveredIn
|
20th century
|
|
gptkbp:example
|
gptkb:diclofenac
gptkb:ibuprofen
gptkb:naproxen
gptkb:aspirin
indomethacin
|
|
gptkbp:excretion
|
kidneys
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NSAIDs
|
|
gptkbp:interactsWith
|
gptkb:SSRIs
ACE inhibitors
diuretics
anticoagulants
|
|
gptkbp:mechanismOfAction
|
inhibit cyclooxygenase enzymes
reduce prostaglandin synthesis
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:notOpioid
|
true
|
|
gptkbp:notRecommendedFor
|
children with viral infections (aspirin)
|
|
gptkbp:notSteroid
|
true
|
|
gptkbp:OTCExample
|
gptkb:ibuprofen
gptkb:naproxen
gptkb:aspirin
|
|
gptkbp:pregnancyCategory
|
varies by drug
|
|
gptkbp:prescriptionExample
|
gptkb:diclofenac
gptkb:ketorolac
indomethacin
|
|
gptkbp:riskFactor
|
Reye's syndrome (aspirin in children)
|
|
gptkbp:routeOfAdministration
|
oral
topical
intravenous
|
|
gptkbp:sideEffect
|
gastrointestinal bleeding
renal impairment
ulcer
increased cardiovascular risk
|
|
gptkbp:standsFor
|
gptkb:Nonsteroidal_anti-inflammatory_drugs
|
|
gptkbp:usedFor
|
pain relief
fever reduction
inflammation reduction
|
|
gptkbp:bfsParent
|
gptkb:Dengue_Fever
gptkb:CYP2C9
gptkb:warfarin
gptkb:Zoloft
gptkb:Avelox
|
|
gptkbp:bfsLayer
|
5
|