|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:affects
|
drug metabolism
drug response
|
|
gptkbp:alternativeName
|
gptkb:CYP2C9
P450IIC9
cytochrome P450 family 2 subfamily C member 9
|
|
gptkbp:catalyzes
|
oxidation of xenobiotics
hydroxylation of drugs
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:EC_number
|
1.14.13.7
|
|
gptkbp:encodedBy
|
CYP2C9 gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:CYP2C9
|
|
gptkbp:expressedIn
|
gptkb:human
mammals
|
|
gptkbp:foundIn
|
gptkb:kidney
gptkb:small_intestine
liver
|
|
gptkbp:gene
|
gptkb:CYP2C9
|
|
gptkbp:hasPolymorphism
|
gptkb:CYP2C9*2
gptkb:CYP2C9*3
|
|
gptkbp:HGNC_ID
|
2593
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
cytochrome P450 2C9
|
|
gptkbp:inducedBy
|
gptkb:rifampin
phenobarbital
|
|
gptkbp:inhibitedBy
|
gptkb:sulfaphenazole
gptkb:fluconazole
amiodarone
|
|
gptkbp:locatedIn
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:locatedOnChromosome
|
chromosome 10q23.33
|
|
gptkbp:member
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:metabolism
|
gptkb:phenytoin
gptkb:warfarin
gptkb:glipizide
gptkb:tolbutamide
gptkb:NSAIDs
gptkb:fluoxetine
gptkb:losartan
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:OMIM
|
601130
|
|
gptkbp:PDB
|
1OG5
|
|
gptkbp:RefSeq
|
NM_000771
|
|
gptkbp:substrate
|
aromatic compounds
steroids
fatty acids
|
|
gptkbp:UniProtID
|
P11712
|
|
gptkbp:bfsParent
|
gptkb:CYP2C9
|
|
gptkbp:bfsLayer
|
5
|