|
gptkbp:instanceOf
|
gptkb:drug
statin
|
|
gptkbp:approvalYear
|
1994
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
gptkb:C10AA04
|
|
gptkbp:bioavailability
|
24-30%
|
|
gptkbp:brand
|
gptkb:Lescol
gptkb:Lescol_XL
|
|
gptkbp:CASNumber
|
93957-55-2
|
|
gptkbp:chemicalFormula
|
C24H26FNO4
|
|
gptkbp:contraindication
|
pregnancy
breastfeeding
active liver disease
|
|
gptkbp:developedBy
|
gptkb:Novartis
|
|
gptkbp:drugClass
|
statin
|
|
gptkbp:eliminationHalfLife
|
1-3 hours
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
fluvastatin
|
|
gptkbp:interactsWith
|
gptkb:cyclosporine
gptkb:phenytoin
gptkb:warfarin
gptkb:erythromycin
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
HMG-CoA reductase inhibitor
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
411.47 g/mol
|
|
gptkbp:pregnancyCategory
|
gptkb:X_(US)
|
|
gptkbp:proteinBinding
|
98%
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
muscle pain
liver enzyme abnormalities
|
|
gptkbp:usedFor
|
gptkb:familial_hypercholesterolemia
prevention of cardiovascular disease
|
|
gptkbp:bfsParent
|
gptkb:CYP2C9
gptkb:Lescol
|
|
gptkbp:bfsLayer
|
5
|