glyburide

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:drug
sulfonylurea
gptkbp:ATCCode A10BB01
gptkbp:Bioavailability 50-100%
gptkbp:brand Diabeta
Glynase
Micronase
gptkbp:CASNumber 10238-21-8
gptkbp:contraindication gptkb:diabetic_ketoacidosis
type 1 diabetes
gptkbp:discoveredBy gptkb:Boehringer_Mannheim
gptkbp:drugClass antidiabetic agent
gptkbp:eliminationHalfLife 10 hours
gptkbp:excretion urine
feces
gptkbp:hasMolecularFormula C23H28ClN3O5S
https://www.w3.org/2000/01/rdf-schema#label glyburide
gptkbp:interactsWith gptkb:beer
gptkb:rifampin
gptkb:warfarin
gptkb:thiazide_diuretics
beta blockers
gptkbp:introducedIn 1969
gptkbp:lactation excreted in breast milk
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction stimulates insulin release from pancreatic beta cells
gptkbp:meltingPoint 179-183°C
gptkbp:metabolism liver
gptkbp:notRecommendedFor children
pregnant women
patients with severe kidney disease
patients with severe liver disease
gptkbp:pregnancyCategory C
gptkbp:prescribes adults
gptkbp:proteinBinding 99%
gptkbp:PubChem_CID gptkb:CHEMBL1431
3367
3488
gptkbp:riskFactor drug interactions
hypoglycemia in elderly
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:hypoglycemia
nausea
weight gain
allergic skin reactions
gptkbp:synonym gptkb:glibenclamide
gptkbp:UNII SX6K58TVWC
gptkbp:usedFor gptkb:type_2_diabetes
gptkbp:bfsParent gptkb:CYP2C9
gptkbp:bfsLayer 5