gptkbp:instanceOf
|
gptkb:drug
sulfonylurea
|
gptkbp:ATCCode
|
A10BB01
|
gptkbp:Bioavailability
|
50-100%
|
gptkbp:brand
|
Diabeta
Glynase
Micronase
|
gptkbp:CASNumber
|
10238-21-8
|
gptkbp:contraindication
|
gptkb:diabetic_ketoacidosis
type 1 diabetes
|
gptkbp:discoveredBy
|
gptkb:Boehringer_Mannheim
|
gptkbp:drugClass
|
antidiabetic agent
|
gptkbp:eliminationHalfLife
|
10 hours
|
gptkbp:excretion
|
urine
feces
|
gptkbp:hasMolecularFormula
|
C23H28ClN3O5S
|
https://www.w3.org/2000/01/rdf-schema#label
|
glyburide
|
gptkbp:interactsWith
|
gptkb:beer
gptkb:rifampin
gptkb:warfarin
gptkb:thiazide_diuretics
beta blockers
|
gptkbp:introducedIn
|
1969
|
gptkbp:lactation
|
excreted in breast milk
|
gptkbp:legalStatus
|
prescription only
|
gptkbp:mechanismOfAction
|
stimulates insulin release from pancreatic beta cells
|
gptkbp:meltingPoint
|
179-183°C
|
gptkbp:metabolism
|
liver
|
gptkbp:notRecommendedFor
|
children
pregnant women
patients with severe kidney disease
patients with severe liver disease
|
gptkbp:pregnancyCategory
|
C
|
gptkbp:prescribes
|
adults
|
gptkbp:proteinBinding
|
99%
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1431
3367
3488
|
gptkbp:riskFactor
|
drug interactions
hypoglycemia in elderly
|
gptkbp:routeOfAdministration
|
oral
|
gptkbp:sideEffect
|
gptkb:hypoglycemia
nausea
weight gain
allergic skin reactions
|
gptkbp:synonym
|
gptkb:glibenclamide
|
gptkbp:UNII
|
SX6K58TVWC
|
gptkbp:usedFor
|
gptkb:type_2_diabetes
|
gptkbp:bfsParent
|
gptkb:CYP2C9
|
gptkbp:bfsLayer
|
5
|