|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:C-X-C_chemokine_receptor_type_2
gptkb:CD182
gptkb:IL8RB
gptkb:interleukin_8_receptor_beta
|
|
gptkbp:associatedWith
|
gptkb:cancer
asthma
inflammatory diseases
chronic obstructive pulmonary disease
rheumatoid arthritis
|
|
gptkbp:biologicalProcess
|
signal transduction
chemokine binding
|
|
gptkbp:discoveredBy
|
1991
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000180871
3579
|
|
gptkbp:expressedIn
|
endothelial cells
monocytes
epithelial cells
neutrophils
|
|
gptkbp:fullName
|
gptkb:C-X-C_chemokine_receptor_type_2
|
|
gptkbp:function
|
gptkb:G_protein-coupled_receptor
chemokine receptor
|
|
gptkbp:gene
|
gptkb:CXCR5
gptkb:CXCR3
gptkb:CXCR6
gptkb:CXCR4
gptkb:CXCR1
|
|
gptkbp:HGNC_ID
|
6026
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CXCR2
|
|
gptkbp:length
|
360 amino acids
|
|
gptkbp:ligand
|
gptkb:CXCL1
gptkb:CXCL2
gptkb:CXCL3
gptkb:CXCL5
gptkb:CXCL6
gptkb:CXCL7
gptkb:CXCL8
gptkb:IL-8
|
|
gptkbp:locatedOnChromosome
|
2q35
chr2:218,991,307-219,003,307
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:MIM_gene
|
146928
|
|
gptkbp:numberOfExons
|
2
|
|
gptkbp:OMIM
|
146928
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Cxcr2
|
|
gptkbp:pathway
|
immune response
chemokine signaling pathway
|
|
gptkbp:PDB
|
gptkb:5T1A
gptkb:6LFL
gptkb:6LFM
gptkb:6LFO
|
|
gptkbp:proteinFamily
|
chemokine receptor family
|
|
gptkbp:RefSeq
|
NM_001557
NP_001548
|
|
gptkbp:regulates
|
downregulated by glucocorticoids
upregulated by inflammatory cytokines
|
|
gptkbp:transmembraneDomains
|
7
|
|
gptkbp:UniProtID
|
gptkb:P25025
|
|
gptkbp:bfsParent
|
gptkb:interleukin-8
gptkb:P15391
gptkb:P84077
gptkb:IL8
gptkb:MIF
gptkb:chemokine_receptors
|
|
gptkbp:bfsLayer
|
7
|