|
gptkbp:instanceOf
|
gptkb:cytokine
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:interleukin-8
|
|
gptkbp:category
|
gptkb:cytokine
gptkb:signaling_molecule
immune system protein
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:encodedBy
|
gptkb:CXCL8_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000169429
|
|
gptkbp:function
|
angiogenesis
inflammatory response
chemotaxis of neutrophils
|
|
gptkbp:gene
|
gptkb:CXCL8
|
|
gptkbp:HGNC_ID
|
6025
|
|
gptkbp:involvedIn
|
wound healing
cancer progression
chronic inflammation
acute inflammation
|
|
gptkbp:length
|
99 amino acids (precursor)
|
|
gptkbp:locatedOnChromosome
|
4q13-q21
|
|
gptkbp:OMIM
|
146930
|
|
gptkbp:orthologInMouse
|
KC (Cxcl1)
|
|
gptkbp:PDB
|
1IL8
|
|
gptkbp:promotion
|
gptkb:IL-1
gptkb:TNF-alpha
oxidative stress
bacterial products
|
|
gptkbp:recipient
|
gptkb:CXCR2
gptkb:CXCR1
|
|
gptkbp:regulates
|
gptkb:NF-kappaB
gptkb:AP-1
|
|
gptkbp:secretes
|
macrophages
endothelial cells
fibroblasts
monocytes
epithelial cells
neutrophils
|
|
gptkbp:significance
|
biomarker for inflammation
target for anti-inflammatory drugs
implicated in asthma
implicated in cancer metastasis
implicated in rheumatoid arthritis
implicated in chronic obstructive pulmonary disease
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
8 kDa protein
|
|
gptkbp:UniProtID
|
P10145
|
|
gptkbp:bfsParent
|
gptkb:interleukin-8
gptkb:P84077
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CXCL8
|