Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
cytokine |
| gptkbp:alsoKnownAs |
gptkb:interleukin-8
|
| gptkbp:category |
signaling molecule
cytokine immune system protein |
| gptkbp:discoveredIn |
1987
|
| gptkbp:encodedBy |
gptkb:CXCL8_gene
|
| gptkbp:Entrez_Gene_ID |
ENSG00000169429
|
| gptkbp:function |
angiogenesis
inflammatory response chemotaxis of neutrophils |
| gptkbp:gene |
gptkb:CXCL8
|
| gptkbp:HGNC_ID |
6025
|
| https://www.w3.org/2000/01/rdf-schema#label |
CXCL8
|
| gptkbp:involvedIn |
wound healing
cancer progression chronic inflammation acute inflammation |
| gptkbp:length |
99 amino acids (precursor)
|
| gptkbp:locatedOnChromosome |
4q13-q21
|
| gptkbp:OMIM |
146930
|
| gptkbp:orthologInMouse |
KC (Cxcl1)
|
| gptkbp:PDB |
1IL8
|
| gptkbp:promotion |
gptkb:IL-1
gptkb:TNF-alpha oxidative stress bacterial products |
| gptkbp:recipient |
gptkb:CXCR2
gptkb:CXCR1 |
| gptkbp:regulates |
gptkb:NF-kappaB
gptkb:AP-1 |
| gptkbp:secretes |
macrophages
endothelial cells fibroblasts monocytes epithelial cells neutrophils |
| gptkbp:significance |
biomarker for inflammation
target for anti-inflammatory drugs implicated in asthma implicated in cancer metastasis implicated in rheumatoid arthritis implicated in chronic obstructive pulmonary disease |
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:structure |
8 kDa protein
|
| gptkbp:UniProtID |
P10145
|
| gptkbp:bfsParent |
gptkb:interleukin-8
gptkb:P15391 gptkb:P84077 gptkb:IL8 |
| gptkbp:bfsLayer |
7
|