C-X-C chemokine receptor type 2

URI: https://gptkb.org/entity/C-X-C_chemokine_receptor_type_2
GPTKB entity
Statements (43)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:G_protein-coupled_receptor
gptkbp:alternativeName gptkb:CD182
gptkb:IL8RB
CDw128b
gptkbp:associatedWith gptkb:cancer
inflammatory diseases
chronic obstructive pulmonary disease
rheumatoid arthritis
gptkbp:cellularComponent gptkb:plasma_membrane
gptkbp:discoveredBy Murphy PM et al.
gptkbp:encodedBy CXCR2 gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000180871
3579
gptkbp:expressedIn endothelial cells
monocytes
neutrophils
gptkbp:family chemokine receptor family
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function involved in inflammatory response
mediates neutrophil chemotaxis
gptkbp:HGNC_ID 6026
https://www.w3.org/2000/01/rdf-schema#label C-X-C chemokine receptor type 2
gptkbp:length 360 amino acids
gptkbp:ligand gptkb:interleukin-8
gptkb:NAP-2
ENA-78
GCP-2
GRO-alpha
GRO-beta
GRO-gamma
gptkbp:locatedOnChromosome 2q35
gptkbp:molecularWeight 41 kDa
gptkbp:OMIM 146928
gptkbp:PDB gptkb:6LFL
gptkb:6LFO
6LFP
gptkbp:RefSeq NM_001557
gptkbp:subfamily CXC chemokine receptor subfamily
gptkbp:transmembraneDomains 7
gptkbp:UniProtID gptkb:P25025
gptkbp:bfsParent gptkb:CXCR2
gptkbp:bfsLayer 8