|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:CD184
Fusin
|
|
gptkbp:discoveredBy
|
gptkb:Ed_Berger
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodes
|
gptkb:C-X-C_chemokine_receptor_type_4_protein
|
|
gptkbp:Entrez_Gene_ID
|
7852
ENSG00000121966
GC02M136366
|
|
gptkbp:expressedIn
|
neurons
hematopoietic cells
endothelial cells
|
|
gptkbp:externalLink
|
https://www.ncbi.nlm.nih.gov/gene/7852
https://www.uniprot.org/uniprot/P61073
|
|
gptkbp:family
|
gptkb:G_protein-coupled_receptor
chemokine receptor family
|
|
gptkbp:fullName
|
gptkb:C-X-C_chemokine_receptor_type_4
|
|
gptkbp:function
|
gptkb:G_protein-coupled_receptor
chemokine receptor
|
|
gptkbp:HGNC_ID
|
HGNC:2561
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CXCR4
|
|
gptkbp:interactsWith
|
gptkb:HIV-1_gp120
gptkb:CXCL12
|
|
gptkbp:involvedIn
|
embryonic development
cell migration
immune response
stem cell homing
|
|
gptkbp:ligand
|
gptkb:CXCL12
|
|
gptkbp:locatedOnChromosome
|
2
2q22.1
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:mutationAssociatedWith
|
gptkb:WHIM_syndrome
immunodeficiency
|
|
gptkbp:OMIM
|
162643
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cxcr4
|
|
gptkbp:regulates
|
regulated by hypoxia
regulated by cytokines
|
|
gptkbp:role
|
gptkb:WHIM_syndrome
HIV infection
immunodeficiency
cancer metastasis
|
|
gptkbp:structure
|
seven transmembrane domains
|
|
gptkbp:target
|
gptkb:AMD3100
gptkb:plerixafor
|
|
gptkbp:UniProtID
|
P61073
|
|
gptkbp:bfsParent
|
gptkb:HIV-1
gptkb:Human_Immunodeficiency_Virus
|
|
gptkbp:bfsLayer
|
6
|