Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:alternativeName |
gptkb:Interleukin-8
|
| gptkbp:discoveredIn |
1987
|
| gptkbp:function |
mediates inflammation
chemoattractant for neutrophils |
| gptkbp:gene |
gptkb:CXCL8
|
| gptkbp:HGNC_ID |
6025
|
| https://www.w3.org/2000/01/rdf-schema#label |
IL-8
|
| gptkbp:involvedIn |
wound healing
angiogenesis immune response tumor progression |
| gptkbp:length |
99
|
| gptkbp:locatedOnChromosome |
4q13-q21
|
| gptkbp:molecularWeight |
8 kDa
|
| gptkbp:OMIM |
146930
|
| gptkbp:orthologIn |
mouse (KC/CXCL1)
rat (CINC-1) |
| gptkbp:PDB |
1IL8
|
| gptkbp:postTranslationalModification |
glycosylation
proteolytic cleavage |
| gptkbp:producedBy |
macrophages
endothelial cells epithelial cells |
| gptkbp:promotion |
gptkb:IL-1
gptkb:TNF-alpha angiogenesis bacterial products neutrophil chemotaxis neutrophil degranulation neutrophil respiratory burst |
| gptkbp:recipient |
gptkb:CXCR2
gptkb:CXCR1 |
| gptkbp:secretes |
gptkb:protein
gptkb:keratinocytes fibroblasts monocytes |
| gptkbp:significance |
elevated in asthma
marker for inflammation elevated in cancer elevated in chronic obstructive pulmonary disease elevated in cystic fibrosis elevated in inflammatory bowel disease elevated in rheumatoid arthritis elevated in sepsis |
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:structureType |
dimer
monomer |
| gptkbp:UniProtID |
P10145
|
| gptkbp:bfsParent |
gptkb:interleukin-8
gptkb:P15391 gptkb:AP1 gptkb:P84077 |
| gptkbp:bfsLayer |
7
|