|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Cell_division_protein_kinase_4
gptkb:Serine/threonine-protein_kinase_CDK4
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:glioblastoma
gptkb:rhabdomyosarcoma
melanoma
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000135446
1019
|
|
gptkbp:enzymeClassification
|
EC 2.7.11.22
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Cyclin-dependent_kinase_4
|
|
gptkbp:function
|
regulation of cell cycle
phosphorylation of retinoblastoma protein
|
|
gptkbp:gene
|
gptkb:CDK4
|
|
gptkbp:HGNC_ID
|
1773
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDK4 protein
|
|
gptkbp:inhibitedBy
|
gptkb:p15INK4b
gptkb:p16INK4a
gptkb:p18INK4c
gptkb:p19INK4d
|
|
gptkbp:interactsWith
|
gptkb:Cyclin_D2
gptkb:Cyclin_D3
gptkb:Cyclin_D1
|
|
gptkbp:locatedOnChromosome
|
12q14
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
34 kDa
|
|
gptkbp:mutationAssociatedWith
|
A296T
D74N
N41S
R24C
R24H
|
|
gptkbp:OMIM
|
123829
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
cell cycle regulation
G1/S transition of mitotic cell cycle
|
|
gptkbp:PDB
|
gptkb:2W96
|
|
gptkbp:phosphorylates
|
gptkb:RB1_protein
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:RefSeq
|
NP_000066.1
|
|
gptkbp:structure
|
protein kinase domain
|
|
gptkbp:target
|
gptkb:palbociclib
gptkb:ribociclib
gptkb:abemaciclib
CDK4/6 inhibitors
|
|
gptkbp:UniProtID
|
P11802
|
|
gptkbp:bfsParent
|
gptkb:CDK4_gene
|
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gptkbp:bfsLayer
|
8
|