|
gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:activatedBy
|
hypophosphorylated RB1
|
|
gptkbp:alsoKnownAs
|
gptkb:retinoblastoma_pathway
|
|
gptkbp:controls
|
cell proliferation
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
|
|
gptkbp:firstDescribed
|
1980s
|
|
gptkbp:function
|
tumor suppression
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RB pathway
|
|
gptkbp:inactivationLeadsTo
|
loss of cell cycle control
|
|
gptkbp:inhibitedBy
|
phosphorylation of RB1
|
|
gptkbp:involves
|
gptkb:cyclin_D
gptkb:RB1_protein
gptkb:p16INK4a
gptkb:CDK4
gptkb:CDK6
gptkb:E2F_transcription_factors
gptkb:cyclin-dependent_kinases
phosphorylation cascade
|
|
gptkbp:mutationAssociatedWith
|
gptkb:RB1_gene
|
|
gptkbp:namedAfter
|
gptkb:retinoblastoma_protein
|
|
gptkbp:prevention
|
uncontrolled cell division
|
|
gptkbp:regulates
|
gptkb:G1/S_transition
cell cycle
|
|
gptkbp:relatedTo
|
p53 pathway
|
|
gptkbp:studiedIn
|
oncology
|
|
gptkbp:target
|
CDK inhibitors
|
|
gptkbp:bfsParent
|
gptkb:p16INK4A
gptkb:p16INK4a-CDK4_pathway
gptkb:CDK4_gene
gptkb:p16INK4a/ARF_pathway
|
|
gptkbp:bfsLayer
|
8
|