Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:biological_pathway
|
| gptkbp:activatedBy |
hypophosphorylated RB1
|
| gptkbp:alsoKnownAs |
gptkb:retinoblastoma_pathway
|
| gptkbp:controls |
cell proliferation
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
|
| gptkbp:firstDescribed |
1980s
|
| gptkbp:function |
tumor suppression
|
| gptkbp:inactivationLeadsTo |
loss of cell cycle control
|
| gptkbp:inhibitedBy |
phosphorylation of RB1
|
| gptkbp:involves |
gptkb:cyclin_D
gptkb:RB1_protein gptkb:p16INK4a gptkb:CDK4 gptkb:CDK6 gptkb:E2F_transcription_factors gptkb:cyclin-dependent_kinases phosphorylation cascade |
| gptkbp:mutationAssociatedWith |
gptkb:RB1_gene
|
| gptkbp:namedAfter |
gptkb:retinoblastoma_protein
|
| gptkbp:prevention |
uncontrolled cell division
|
| gptkbp:regulates |
gptkb:G1/S_transition
cell cycle |
| gptkbp:relatedTo |
p53 pathway
|
| gptkbp:studiedIn |
oncology
|
| gptkbp:target |
CDK inhibitors
|
| gptkbp:bfsParent |
gptkb:CDK4_gene
gptkb:p16INK4a/ARF_pathway |
| gptkbp:bfsLayer |
8
|
| https://www.w3.org/2000/01/rdf-schema#label |
RB pathway
|