gptkbp:instanceOf
|
gptkb:gene
|
gptkbp:alsoKnownAs
|
gptkb:LKB1
|
gptkbp:associatedSyndrome
|
gptkb:Peutz-Jeghers_syndrome
|
gptkbp:discoveredBy
|
gptkb:Hemminki_et_al.
|
gptkbp:discoveredIn
|
1997
|
gptkbp:encodes
|
gptkb:serine/threonine_kinase_11
|
gptkbp:Entrez_Gene_ID
|
6794
ENSG00000118046
|
gptkbp:expressedIn
|
many tissues
|
gptkbp:function
|
tumor suppressor
regulation of metabolism
regulation of cell polarity
|
gptkbp:HGNC_ID
|
11389
|
https://www.w3.org/2000/01/rdf-schema#label
|
STK11
|
gptkbp:length
|
433 amino acids
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.3
gptkb:chromosome_19
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Peutz-Jeghers_syndrome
pancreatic cancer
germline
increased cancer risk
somatic
hamartomatous polyps
mucocutaneous pigmentation
|
gptkbp:OMIM
|
602216
|
gptkbp:orthologInMouse
|
gptkb:Stk11
|
gptkbp:orthologInZebrafish
|
gptkb:stk11a
|
gptkbp:phosphorylates
|
gptkb:AMPK
gptkb:BRSK_family_proteins
gptkb:MARK_family_proteins
gptkb:SIK_family_proteins
|
gptkbp:product
|
gptkb:LKB1_protein
|
gptkbp:proteinFamily
|
gptkb:serine/threonine_kinase_family
kinase domain
C-terminal domain
N-terminal domain
|
gptkbp:regulates
|
gptkb:AMPK_pathway
gptkb:mTOR_pathway
apoptosis
cell proliferation
lipid metabolism
cell migration
energy metabolism
autophagy
cell polarity
cell cycle arrest
glucose homeostasis
|
gptkbp:UniProtID
|
Q15831
|
gptkbp:bfsParent
|
gptkb:19p13.3
|
gptkbp:bfsLayer
|
6
|