|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:APO-1
gptkb:CD95
gptkb:TNFRSF6
|
|
gptkbp:clinicalTrialPhase
|
yes
|
|
gptkbp:discoveredBy
|
gptkb:Peter_H._Krammer
|
|
gptkbp:encodes
|
gptkb:Fas_cell_surface_death_receptor
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000026103
355
|
|
gptkbp:expressedIn
|
various tissues including immune cells
|
|
gptkbp:firstDescribed
|
1989
|
|
gptkbp:function
|
regulation of programmed cell death (apoptosis)
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:11920
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FAS gene
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:caspase-8
gptkb:Fas_ligand_(FasL)
|
|
gptkbp:involvedIn
|
immune system regulation
apoptotic signaling pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
gptkb:10q23.31
|
|
gptkbp:memberOf
|
gptkb:tumor_necrosis_factor_receptor_superfamily
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:autoimmune_lymphoproliferative_syndrome_(ALPS)
gptkb:systemic_lupus_erythematosus
multiple sclerosis
nonsense
type 1 diabetes
missense
hepatitis
rheumatoid arthritis
frameshift
splice site
|
|
gptkbp:OMIM
|
134637
|
|
gptkbp:orthologInFruitFly
|
gptkb:Wengen
|
|
gptkbp:orthologInMouse
|
gptkb:Fas_(mouse_gene)
gptkb:Fas_(rat_gene)
gptkb:Fas_gene
|
|
gptkbp:orthologInZebrafish
|
gptkb:fas_(zebrafish_gene)
|
|
gptkbp:product
|
gptkb:Fas_receptor
transmembrane protein
|
|
gptkbp:proteinFamily
|
death domain
|
|
gptkbp:regulates
|
upregulated by p53
regulated by NF-κB
regulated by cytokines
|
|
gptkbp:target
|
therapeutic antibodies
experimental cancer therapies
|
|
gptkbp:UniProtID
|
gptkb:P25445
|
|
gptkbp:bfsParent
|
gptkb:Fas
gptkb:Fas_receptor
|
|
gptkbp:bfsLayer
|
6
|