|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:FADD
death receptors
|
|
gptkbp:alias
|
gptkb:FLICE
gptkb:MACH
gptkb:Mch5
apoptotic cysteine protease
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
|
|
gptkbp:catalyzes
|
cleavage of aspartic acid peptide bonds
|
|
gptkbp:cleavage
|
gptkb:caspase-3
gptkb:caspase-7
gptkb:Bid
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:EC_number
|
3.4.22.61
|
|
gptkbp:formsComplexWith
|
gptkb:FADD
gptkb:death-inducing_signaling_complex_(DISC)
gptkb:procaspase-8
|
|
gptkbp:function
|
gptkb:protease
initiator caspase in apoptosis
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
caspase-8
|
|
gptkbp:inhibitedBy
|
gptkb:c-FLIP
|
|
gptkbp:involvedIn
|
immune response regulation
extrinsic apoptotic signaling pathway
|
|
gptkbp:locatedOnChromosome
|
2q33-q34
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:mutationAssociatedWith
|
immunodeficiency
lymphoproliferative disorders
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
gptkb:1QTN
|
|
gptkbp:product
|
gptkb:CASP8_gene
|
|
gptkbp:regulates
|
inflammation
cell death
|
|
gptkbp:reviewedBy
|
gptkb:Nature
gptkb:Cell_Death_and_Differentiation
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:Q14790
|
|
gptkbp:bfsParent
|
gptkb:Fas
gptkb:Fas_receptor
|
|
gptkbp:bfsLayer
|
6
|