|
gptkbp:instanceOf
|
gptkb:protein
cell surface receptor
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:antibodyTarget
|
gptkb:Abatacept
Belatacept
FR104
|
|
gptkbp:binds
|
gptkb:CD80
gptkb:CD86
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
CD28 gene
|
|
gptkbp:Entrez_Gene_ID
|
940
|
|
gptkbp:expressedIn
|
gptkb:T_cells
gptkb:regulatory_T_cells
memory T cells
|
|
gptkbp:foundIn
|
humans
mice
|
|
gptkbp:function
|
T cell activation
costimulatory molecule
|
|
gptkbp:gene
|
gptkb:CD28
|
|
gptkbp:HGNC_ID
|
1653
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD28
|
|
gptkbp:interactsWith
|
gptkb:PI3K
gptkb:Grb2
gptkb:Lck
|
|
gptkbp:involvedIn
|
immune response
|
|
gptkbp:locatedOnChromosome
|
2q33.2 (human)
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:notExpressedOn
|
gptkb:NK_cells
gptkb:B_cells
monocytes
|
|
gptkbp:OMIM
|
186760
|
|
gptkbp:phosphorylates
|
Y191
Y218
|
|
gptkbp:relatedTo
|
gptkb:CTLA-4
gptkb:ICOS
|
|
gptkbp:requires
|
cytokine production
T cell proliferation
|
|
gptkbp:role
|
gptkb:allergy
autoimmunity
cancer immunology
transplant rejection
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
type I transmembrane protein
|
|
gptkbp:target
|
immunotherapy
|
|
gptkbp:UniProtID
|
P10747
|
|
gptkbp:bfsParent
|
gptkb:cell_surface_receptor
|
|
gptkbp:bfsLayer
|
6
|