Abatacept

GPTKB entity

Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:drug
immunosuppressive agent
gptkbp:administeredBy intravenous infusion
subcutaneous injection
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
2005
gptkbp:ATCCode L04AA24
gptkbp:brand gptkb:Orencia
gptkbp:CASNumber 332348-12-6
gptkbp:contains gptkb:CTLA-4
IgG1 Fc region
gptkbp:contraindication serious infections
hypersensitivity to abatacept
gptkbp:developedBy gptkb:Bristol-Myers_Squibb
gptkbp:drugClass selective immunosuppressant
gptkbp:form solution for injection
lyophilized powder for infusion
gptkbp:halfLife 13-16 days
https://www.w3.org/2000/01/rdf-schema#label Abatacept
gptkbp:interactsWith live vaccines
TNF inhibitors
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction selective T-cell co-stimulation modulator
gptkbp:molecularWeight 92 kDa
gptkbp:monitors liver function tests
infection surveillance
gptkbp:notRecommendedFor children under 2 years
gptkbp:pregnancyCategory C (US)
gptkbp:prescribes moderate to severe rheumatoid arthritis
polyarticular juvenile idiopathic arthritis
active psoriatic arthritis
gptkbp:product gptkb:protein
gptkbp:routeOfAdministration subcutaneous
intravenous
gptkbp:sideEffect nausea
headache
hypertension
infections
gptkbp:storage 2-8°C
gptkbp:target gptkb:CD80
gptkb:CD86
gptkbp:UNII 3KX376GY7L
gptkbp:usedFor gptkb:juvenile_idiopathic_arthritis
gptkb:psoriatic_arthritis
rheumatoid arthritis
gptkbp:bfsParent gptkb:CD28
gptkbp:bfsLayer 7