|
gptkbp:instanceOf
|
immune response
|
|
gptkbp:alsoKnownAs
|
Tregs
|
|
gptkbp:canBe
|
induced Tregs
natural Tregs
|
|
gptkbp:deficiencyCauses
|
autoimmune disease
|
|
gptkbp:describedYear
|
1995
|
|
gptkbp:developIn
|
gptkb:thymus
|
|
gptkbp:expansion
|
gptkb:cancer
|
|
gptkbp:expressedIn
|
gptkb:FOXP3
gptkb:CD4
gptkb:CD25
|
|
gptkbp:firstDescribed
|
gptkb:Shimon_Sakaguchi
|
|
gptkbp:foundIn
|
lymph nodes
spleen
peripheral blood
mucosal tissues
|
|
gptkbp:function
|
suppress immune response
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
regulatory T cells
|
|
gptkbp:involvedIn
|
immune tolerance
prevention of autoimmunity
|
|
gptkbp:marking
|
gptkb:CTLA-4
gptkb:CD4
gptkb:CD25
gptkb:GITR
gptkb:CD39
CD127low
CD73
|
|
gptkbp:reduces
|
autoimmune diseases
|
|
gptkbp:regulates
|
gptkb:natural_killer_cells
gptkb:FOXP3
gptkb:B_cells
dendritic cells
macrophages
effector T cells
|
|
gptkbp:role
|
gptkb:allergy
autoimmune diseases
cancer immunology
transplant tolerance
|
|
gptkbp:secretes
|
gptkb:IL-10
gptkb:TGF-beta
|
|
gptkbp:subclassOf
|
gptkb:T_cells
|
|
gptkbp:suppressVia
|
cell-cell contact
cytokine secretion
metabolic disruption
modulation of dendritic cells
|
|
gptkbp:target
|
gptkb:cancer
immunotherapy
autoimmune disease therapy
|
|
gptkbp:bfsParent
|
gptkb:Interleukin-2
gptkb:interleukin-6
gptkb:CD25
|
|
gptkbp:bfsLayer
|
6
|