|
gptkbp:instanceOf
|
gptkb:protein
immunotherapy
|
|
gptkbp:alternativeName
|
gptkb:CD152
|
|
gptkbp:binds
|
gptkb:CD80
gptkb:CD86
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:encodedBy
|
gptkb:CTLA4_gene
|
|
gptkbp:Entrez_Gene_ID
|
1493
|
|
gptkbp:expressedIn
|
gptkb:T_cells
|
|
gptkbp:foundIn
|
humans
mice
|
|
gptkbp:fullName
|
gptkb:Cytotoxic_T-lymphocyte-associated_protein_4
|
|
gptkbp:function
|
inhibits T cell activation
|
|
gptkbp:HGNC_ID
|
2500
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CTLA-4
|
|
gptkbp:inhibitedBy
|
CD28-mediated co-stimulation
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_2q33
|
|
gptkbp:location
|
intracellular vesicles
cell surface
|
|
gptkbp:mutationAssociatedWith
|
gptkb:autoimmune_lymphoproliferative_syndrome
Graves' disease
type 1 diabetes
rheumatoid arthritis
|
|
gptkbp:OMIM
|
123890
|
|
gptkbp:orthologIn
|
gptkb:mouse
right
|
|
gptkbp:PDB
|
3OSK
|
|
gptkbp:regulates
|
immune response
|
|
gptkbp:reviewedBy
|
gptkb:The_Journal_of_Immunology
gptkb:Nature_Reviews_Immunology
|
|
gptkbp:role
|
immunotherapy
autoimmune disease
|
|
gptkbp:structureType
|
transmembrane protein
|
|
gptkbp:target
|
gptkb:abatacept
gptkb:belatacept
gptkb:ipilimumab
|
|
gptkbp:UniProtID
|
P16410
|
|
gptkbp:bfsParent
|
gptkb:James_P._Allison
|
|
gptkbp:bfsLayer
|
5
|