|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
p56lck
Lymphocyte protein tyrosine kinase
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
leukemia
autoimmune diseases
|
|
gptkbp:discoveredBy
|
T. A. Mustelin et al.
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000182866
|
|
gptkbp:enzymeClassification
|
EC 2.7.10.2
|
|
gptkbp:expressedIn
|
gptkb:NK_cells
gptkb:T_cells
|
|
gptkbp:family
|
gptkb:Src_family_kinases
|
|
gptkbp:fullName
|
gptkb:Lymphocyte-specific_protein_tyrosine_kinase
|
|
gptkbp:function
|
signal transduction
T cell activation
|
|
gptkbp:gene
|
gptkb:LCK
|
|
gptkbp:GO
|
gptkb:GO:0004713
|
|
gptkbp:HGNC_ID
|
HGNC:6524
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Lck
|
|
gptkbp:inhibitedBy
|
gptkb:PP2
Dasatinib
|
|
gptkbp:interactsWith
|
gptkb:PI3K
gptkb:Fyn
gptkb:CD45
gptkb:ZAP-70
gptkb:LAT
gptkb:CD4
gptkb:CD8
Csk
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
|
|
gptkbp:location
|
inner leaflet of plasma membrane
|
|
gptkbp:molecularWeight
|
56 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Mus musculus Lck
Rattus norvegicus Lck
|
|
gptkbp:pathway
|
gptkb:T_cell_receptor_signaling_pathway
immune response
|
|
gptkbp:PDB
|
gptkb:3LCK
|
|
gptkbp:phosphorylates
|
gptkb:CD3
gptkb:ZAP-70
ITAMs
|
|
gptkbp:postTranslationalModification
|
palmitoylation
phosphorylation
myristoylation
|
|
gptkbp:RefSeq
|
NP_005347
|
|
gptkbp:regulates
|
phosphorylation
dephosphorylation
binding to CD45
binding to Csk
|
|
gptkbp:structure
|
contains SH2, SH3, and kinase domains
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
lipid rafts
|
|
gptkbp:UniProtID
|
P06239
|
|
gptkbp:bfsParent
|
gptkb:Src
gptkb:CD28
gptkb:Src_family_kinases
gptkb:PTPRC
gptkb:PKC_theta
|
|
gptkbp:bfsLayer
|
7
|