|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:B7-2
gptkb:CD28LG2
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
transplant rejection
|
|
gptkbp:binds
|
gptkb:CD28
gptkb:CTLA-4
|
|
gptkbp:biologicalProcess
|
T cell activation
immune system process
cell-cell signaling
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:disulfideBond
|
yes
|
|
gptkbp:encodedBy
|
gptkb:CD86_gene
|
|
gptkbp:Entrez_Gene_ID
|
942
ENSG00000114013
|
|
gptkbp:expressedIn
|
gptkb:B_cells
dendritic cells
macrophages
antigen-presenting cells
immune activation
|
|
gptkbp:extracellularDomain
|
immunoglobulin-like
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
immune response regulation
costimulatory molecule
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
gptkb:GO:0001772
GO:0009897
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:1704
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD86
|
|
gptkbp:interactsWith
|
gptkb:CD80
PD-L1
|
|
gptkbp:locatedOnChromosome
|
3
3q13.33
|
|
gptkbp:memberOf
|
gptkb:B7_family
|
|
gptkbp:MIM_gene
|
601020
|
|
gptkbp:molecularWeight
|
~80 kDa
|
|
gptkbp:N-glycosylation
|
yes
|
|
gptkbp:OMIM
|
601020
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1I8L
|
|
gptkbp:regulates
|
upregulated by cytokines
downregulated by CTLA-4
|
|
gptkbp:structureType
|
type I transmembrane glycoprotein
|
|
gptkbp:target
|
gptkb:abatacept
gptkb:belatacept
immunotherapy
|
|
gptkbp:UniProtID
|
P42081
|
|
gptkbp:bfsParent
|
gptkb:CTLA-4
|
|
gptkbp:bfsLayer
|
6
|