Statements (25)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
cell surface receptor |
| gptkbp:alsoKnownAs |
gptkb:CD22
|
| gptkbp:binds |
sialic acid-containing glycoproteins
|
| gptkbp:contains |
immunoreceptor tyrosine-based inhibitory motifs (ITIMs)
|
| gptkbp:encodedBy |
gptkb:CD22_gene
|
| gptkbp:expressedIn |
lymphoid tissues
|
| gptkbp:foundIn |
gptkb:B_cells
|
| gptkbp:function |
inhibition of B cell activation
regulation of B cell receptor signaling |
| https://www.w3.org/2000/01/rdf-schema#label |
Siglec-2
|
| gptkbp:interactsWith |
SH2 domain-containing proteins
|
| gptkbp:locatedOnChromosome |
chromosome 19q13.1
|
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:memberOf |
gptkb:immunoglobulin_superfamily
gptkb:Siglec_family |
| gptkbp:molecularWeight |
approximately 140 kDa
|
| gptkbp:OMIM |
107266
|
| gptkbp:role |
autoimmunity
B cell tolerance |
| gptkbp:target |
therapeutic antibodies
|
| gptkbp:UniProtID |
gptkb:P20273
|
| gptkbp:usedAs |
B cell marker
|
| gptkbp:bfsParent |
gptkb:CD22
|
| gptkbp:bfsLayer |
7
|