|
gptkbp:instanceOf
|
gptkb:protein
gptkb:cell_surface_receptor
|
|
gptkbp:alsoKnownAs
|
gptkb:CD22
|
|
gptkbp:binds
|
sialic acid-containing glycoproteins
|
|
gptkbp:contains
|
immunoreceptor tyrosine-based inhibitory motifs (ITIMs)
|
|
gptkbp:encodedBy
|
gptkb:CD22_gene
|
|
gptkbp:expressedIn
|
lymphoid tissues
|
|
gptkbp:foundIn
|
gptkb:B_cells
|
|
gptkbp:function
|
inhibition of B cell activation
regulation of B cell receptor signaling
|
|
gptkbp:interactsWith
|
SH2 domain-containing proteins
|
|
gptkbp:locatedOnChromosome
|
chromosome 19q13.1
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:memberOf
|
gptkb:immunoglobulin_superfamily
gptkb:Siglec_family
|
|
gptkbp:molecularWeight
|
approximately 140 kDa
|
|
gptkbp:OMIM
|
107266
|
|
gptkbp:role
|
autoimmunity
B cell tolerance
|
|
gptkbp:target
|
therapeutic antibodies
|
|
gptkbp:UniProtID
|
gptkb:P20273
|
|
gptkbp:usedAs
|
B cell marker
|
|
gptkbp:bfsParent
|
gptkb:CD22
gptkb:sialic_acid-binding_immunoglobulin-like_lectins_(Siglecs)
gptkb:Siglec_family
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Siglec-2
|