|
gptkbp:instanceOf
|
gptkb:disease
leukemia
|
|
gptkbp:affects
|
lymphatic system
|
|
gptkbp:associatedWith
|
gptkb:t(11;14)(q13;q32)_translocation
overexpression of cyclin D1
|
|
gptkbp:common_symptom
|
fever
weight loss
lymphadenopathy
night sweats
|
|
gptkbp:diagnosedBy
|
lymph node biopsy
immunohistochemistry
flow cytometry
|
|
gptkbp:firstDescribed
|
1970s
|
|
gptkbp:hasVariant
|
blastoid variant
pleomorphic variant
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mantle cell lymphoma
|
|
gptkbp:ICD-10_code
|
gptkb:C83.1
|
|
gptkbp:incidence
|
rare
|
|
gptkbp:marking
|
gptkb:cyclin_D1
gptkb:CD20
gptkb:SOX11
CD5
|
|
gptkbp:mayInclude
|
gastrointestinal tract
liver
spleen
bone marrow
peripheral blood
|
|
gptkbp:median_age_at_diagnosis
|
60 years
|
|
gptkbp:more_common_in
|
males
|
|
gptkbp:namedAfter
|
mantle zone of lymph node
|
|
gptkbp:not_associated_with
|
gptkb:Epstein-Barr_virus
|
|
gptkbp:notable_treatment
|
gptkb:rituximab
gptkb:bortezomib
gptkb:ibrutinib
|
|
gptkbp:originatedIn
|
gptkb:B_lymphocytes
|
|
gptkbp:prognosis
|
generally poor
|
|
gptkbp:rare_in
|
children
|
|
gptkbp:riskFactor
|
immunosuppression
older age
male gender
|
|
gptkbp:specialty
|
oncology
hematology
|
|
gptkbp:subtype_of
|
B-cell lymphoma
|
|
gptkbp:treatment
|
chemotherapy
immunotherapy
targeted therapy
stem cell transplant
|
|
gptkbp:WHOClassification
|
mature B-cell neoplasm
|
|
gptkbp:bfsParent
|
gptkb:parsaclisib
gptkb:Tecartus
gptkb:CAR-T_cell
gptkb:Calquence
|
|
gptkbp:bfsLayer
|
6
|